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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2022; 14(9): 940-949
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.940
Published online Sep 27, 2022. doi: 10.4240/wjgs.v14.i9.940
Development of an innovative nomogram of risk factors to predict postoperative recurrence of gastrointestinal stromal tumors
Shi-Hao Guan, Department of General Surgery, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China
Shi-Hao Guan, Medical College, Qinghai University, Xining 810001, Qinghai Province, China
Qiong Wang, Department of Medical Oncology, The Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China
Xiao-Ming Ma, Wen-Jie Qiao, Ming-Zheng Li, Ming-Gui Lai, Cheng Wang, Department of Gastrointestinal Tumor Surgery, The Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China
Author contributions: Guan SH is the author of the main idea, conceived and designed the study, collected and analyzed the data, and wrote and revised the manuscript; Wang C conceived and designed the study, collected and analyzed the data and wrote the manuscript; Wang Q and Ma XM participated in drafting and revising the manuscript, and collected the data; Qiao WJ, Li MZ and Lai MG revised the manuscript and analyzed the data. All authors approved the final version of the manuscript.
Institutional review board statement: This study was approved by the Institutional Research Ethics Board of Qinghai University Affiliated Hospital (Xining, China) and followed the Declaration of Helsinki.
Informed consent statement: All patients signed informed consent forms.
Conflict-of-interest statement: Each author in this paper declares no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cheng Wang, MM, Chief Doctor, Professor, Department of Gastrointestinal Tumor Surgery, The Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining 810001, Qinghai Province, China. cheng_wang_vip@163.com
Received: April 14, 2022
Peer-review started: April 14, 2022
First decision: June 10, 2022
Revised: July 2, 2022
Accepted: August 7, 2022
Article in press: August 7, 2022
Published online: September 27, 2022
Processing time: 161 Days and 0.3 Hours
Peer-review started: April 14, 2022
First decision: June 10, 2022
Revised: July 2, 2022
Accepted: August 7, 2022
Article in press: August 7, 2022
Published online: September 27, 2022
Processing time: 161 Days and 0.3 Hours
Core Tip
Core Tip: This is a retrospective study to explore the risk factors for gastrointestinal stromal tumors recurrence after surgery. The nomogram included tumor site, lesion size, mitotic rate/50 high power fields, Ki-67 index, intracranial necrosis, and age as predictors. The model presented perfect discrimination with a reliable index of concordance (C-index) of 0.836 (95%CI: 0.712-0.960), and a high C-index value of 0.714 was also confirmed by interval validation. The area under the curve value of this prediction nomogram was 0.704, indicating good predictive value. Decision curve analysis showed that the predicting recurrence nomogram was clinically feasible.