Dou XJ, Wang QP, Liu WH, Weng YQ, Sun Y, Yu WL. Effect of cardiac output - guided hemodynamic management on acute lung injury in pediatric living donor liver transplantation. World J Gastrointest Surg 2022; 14(9): 1037-1048 [PMID: 36185553 DOI: 10.4240/wjgs.v14.i9.1037]
Corresponding Author of This Article
Wen-Li Yu, Doctor, PhD, Chief Doctor, Department of Anesthesiology, Tianjin First Central Hospital, No. 24 Fukang Road, Tianjin 300192, China. yzxyuwenli@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Randomized Controlled Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Jing Dou, Qing-Ping Wang, Wei-Hua Liu, Yi-Qi Weng, Ying Sun, Wen-Li Yu, Department of Anesthesiology, Tianjin First Central Hospital, Tianjin 300192, China
Author contributions: Dou XJ contributed to acquisition of data, data analysis, and wrote the manuscript; Yu WL provided substantial contribution to the conception and design of the study and corrected the manuscript; Wang QP, Liu WH, Weng YQ, and Sun Y collected the data.
Institutional review board statement: This study was approved by the Ethics Committee of Tianjin First Center Hospital in China (Approval Number: 2019N180KY).
Clinical trial registration statement: The clinical trial registration number is ChiCTR1900026016.
Informed consent statement: Informed consent was obtained from eligible guardians.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data would be shared under proper request for the corresponding author.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Li Yu, Doctor, PhD, Chief Doctor, Department of Anesthesiology, Tianjin First Central Hospital, No. 24 Fukang Road, Tianjin 300192, China. yzxyuwenli@163.com
Received: March 18, 2022 Peer-review started: March 18, 2022 First decision: May 12, 2022 Revised: May 25, 2022 Accepted: August 14, 2022 Article in press: August 14, 2022 Published online: September 27, 2022 Processing time: 188 Days and 8.1 Hours
Core Tip
Core Tip: This is the first randomized controlled trial to evaluate the effect of cardiac output (CO)-guided hemodynamic therapy in pediatric liver recipients. In this study, hemodynamic parameters, including CO, stroke volume index, stroke volume variation, and the maximum increase in the speed of intraventricular pressure (dp/dtmax) obtained through the pressure recording analytical method monitoring were used to guide intraoperative hemodynamic management. The incidence of postoperative acute liver injury was significantly lower in the interventional group. Moreover, the inflammatory factors (interleukin-6 and tumor necrosis factor-α), cardiac troponin I, and N-terminal pro-brain natriuretic peptide levels decreased faster in the intervention group.
