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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2022; 14(2): 161-173
Published online Feb 27, 2022. doi: 10.4240/wjgs.v14.i2.161
Published online Feb 27, 2022. doi: 10.4240/wjgs.v14.i2.161
Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy: A propensity score matching analysis
Hai-Tao Hu, Fu-Hai Ma, Jian-Ping Xiong, Yang Li, Peng Jin, Hao Liu, Shuai Ma, Wen-Zhe Kang, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, Beijing Province, China
Author contributions: Hu HT contributed to the design of the study, collected data and drafted the manuscript; Ma FH and Xiong JP performed the data analyses and revised the manuscript; Li Y, Jin P and Liu H helped perform the analysis with constructive discussions; Ma S and Kang WZ contributed to manuscript preparation data for the work; Tian YT conceived the work that led to the submission and approved the final version; and all authors issued final approval for the version to be submitted.
Supported by National Natural Science Foundation of China , No. 81772642 .
Institutional review board statement: This study was approved by the Ethics Committee of the Cancer Hospital of the Chinese Academy of Medical Sciences (No.14-067/857).
Informed consent statement: This study obtained informed consent exemptions approved by the Ethics Committee of the Cancer Hospital of the Chinese Academy of Medical Sciences.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Tao Tian, MD, Chief Doctor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, Beijing Province, China. tianyantao@cicams.ac.cn
Received: July 15, 2021
Peer-review started: July 15, 2021
First decision: November 8, 2021
Revised: December 13, 2021
Accepted: February 10, 2022
Article in press: February 10, 2022
Published online: February 27, 2022
Peer-review started: July 15, 2021
First decision: November 8, 2021
Revised: December 13, 2021
Accepted: February 10, 2022
Article in press: February 10, 2022
Published online: February 27, 2022
Core Tip
Core Tip: Laparoscopic total gastrectomy (LTG) is known to have better short-term outcomes and prognosis than open TG (OTG) in early gastric cancer (GC). However, its application in advanced GC remains controversial. In this study, we evaluated both long- and short-term outcomes of LTG compared to those of OTG in 185 patients with advanced GC who had received neoadjuvant therapy (NAT). Our results indicate that LTG is associated with better short-term and comparable long-term outcomes compared to the traditional OTG surgery. Therefore, it can be a feasible surgical treatment for advanced GC patients following NAT.