Hu HT, Ma FH, Xiong JP, Li Y, Jin P, Liu H, Ma S, Kang WZ, Tian YT. Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy: A propensity score matching analysis. World J Gastrointest Surg 2022; 14(2): 161-173 [PMID: 35317541 DOI: 10.4240/wjgs.v14.i2.161]
Corresponding Author of This Article
Yan-Tao Tian, MD, Chief Doctor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, Beijing Province, China. tianyantao@cicams.ac.cn
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hai-Tao Hu, Fu-Hai Ma, Jian-Ping Xiong, Yang Li, Peng Jin, Hao Liu, Shuai Ma, Wen-Zhe Kang, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, Beijing Province, China
Author contributions: Hu HT contributed to the design of the study, collected data and drafted the manuscript; Ma FH and Xiong JP performed the data analyses and revised the manuscript; Li Y, Jin P and Liu H helped perform the analysis with constructive discussions; Ma S and Kang WZ contributed to manuscript preparation data for the work; Tian YT conceived the work that led to the submission and approved the final version; and all authors issued final approval for the version to be submitted.
Supported byNational Natural Science Foundation of China, No. 81772642.
Institutional review board statement: This study was approved by the Ethics Committee of the Cancer Hospital of the Chinese Academy of Medical Sciences (No.14-067/857).
Informed consent statement: This study obtained informed consent exemptions approved by the Ethics Committee of the Cancer Hospital of the Chinese Academy of Medical Sciences.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Tao Tian, MD, Chief Doctor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, Beijing Province, China. tianyantao@cicams.ac.cn
Received: July 15, 2021 Peer-review started: July 15, 2021 First decision: November 8, 2021 Revised: December 13, 2021 Accepted: February 10, 2022 Article in press: February 10, 2022 Published online: February 27, 2022
ARTICLE HIGHLIGHTS
Research background
Laparoscopic total gastrectomy (LTG) has been widely used these days. Its surgical and oncological outcomes following neoadjuvant therapy (NAT) is still unkown.
Research motivation
To compare the long- and short-term outcomes between LTG and open TG (OTG) following NAT.
Research objectives
Advanced gastric cancer (GC) patients who underwent TG following NAT.
Research methods
Patients were divided into two groups: LTG and OTG. Propensity score matching analysis was performed to minimize possible bias.
Research results
LTG had advantages in short-term outcomes, such as shorter length of hospital stay (P = 0.012), and the oncological outcomes were close to OTG. Overall survival (OS) outcomes were comparable between the two groups. Pathological T and N stages were independent risk factors for OS.
Research conclusions
LTG can be a safe and effective method for advanced GC patients following NAT.
Research perspectives
Further high-volume, prospective, and multi-center clinical trials are required to evaluate the surgical and oncological outcomes of LTG.
