Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2024; 16(1): 59-66
Published online Jan 27, 2024. doi: 10.4240/wjgs.v16.i1.59
Computerized tomography-guided therapeutic percutaneous puncture catheter drainage-combined with somatostatin for severe acute pancreatitis: An analysis of efficacy and safety
Xue-Lan Zheng, Wan-Ling Li, Yan-Ping Lin, Ting-Long Huang
Xue-Lan Zheng, Yan-Ping Lin, Ting-Long Huang, Department of Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Wan-Ling Li, CT Room, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Author contributions: Zheng XL, and Huang TL designed the research and wrote the first manuscript; Zheng XL, Li WL, Lin YP, and Huang TL contributed to conceiving the research and analyzing data, conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Supported by 2022 Fujian Medical University Qihang Fund General Project Plan, No. 2022QH1120.
Institutional review board statement: This study was approved by the Ethic Committee of The Second Affiliated Hospital of Fujian Medical University. Fuyi Fuer Ethics Review No. (322).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting-Long Huang, Doctor, Staff Physician, Department of Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Licheng District, Quanzhou 362000, Fujian Province, China. htl1203@163.com
Received: October 30, 2023
Peer-review started: October 30, 2023
First decision: November 8, 2023
Revised: December 6, 2023
Accepted: December 18, 2023
Article in press: December 18, 2023
Published online: January 27, 2024
ARTICLE HIGHLIGHTS
Research background

Severe acute pancreatitis (SAP) accounts for 20% of all acute pancreatitis cases and poses a more serious threat to human health, so it is necessary to provide timely intervention to patients to improve their outcomes and ensure a certain therapeutic effect.

Research motivation

In view of the limited studies on the efficacy and safety of somatostatin (SS) combined with computerized tomography-guided therapeutic percutaneous puncture catheter drainage (CT-TPPCD) in the treatment of SAP, this study aims to supplement the gaps in this area and provide reliable clinical guidance.

Research objectives

To analyze the efficacy and safety of CT-TPPCD combined with SS in the treatment of SAP.

Research methods

Forty-two SAP patients were included, including 20 cases (control group) treated with SS intervention and 22 cases (research group) with CT-TPPCD + SS intervention. Comparative analyses were conducted from the following perspectives: Efficacy, safety (pancreatic fistula, intraperitoneal hemorrhage, sepsis, and organ dysfunction syndrome), abdominal bloating and pain relief time, intestinal recovery time, length of hospital stay, inflammatory indicators (C-reactive protein, interleukin-6, and procalcitonin), and Acute Physiology and Chronic Health Evaluation (APACHE) II score.

Research results

The research group showed a higher total effective rate than the control group, with faster relief of abdominal bloating and pain and intestinal recovery, shorter length of hospital stay, and fewer adverse events, all with statistical significance. In addition, lower levels of inflammation indexes and APACHE II scores were determined in the research group after treatment, significantly lower than the baseline and those of the control group.

Research conclusions

CT-TPPCD plus SS is highly effective and safe in the treatment of SAP patients, contributing to fast inhibition of patients' disease and effective alleviation of serum inflammatory responses, which is worthy of clinical promotion.

Research perspectives

The negative impact of SAP on patients should not be underestimated, and it is necessary to improve clinical efficacy from the perspective of treatment optimization. This study proposes that SS combined with CT-TPPCD is significantly superior to SS alone in the treatment of SAP, which is of great significance for improving the clinical outcome of SAP patients and provides new clinical basis and insights.