Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2024; 16(1): 59-66
Published online Jan 27, 2024. doi: 10.4240/wjgs.v16.i1.59
Computerized tomography-guided therapeutic percutaneous puncture catheter drainage-combined with somatostatin for severe acute pancreatitis: An analysis of efficacy and safety
Xue-Lan Zheng, Wan-Ling Li, Yan-Ping Lin, Ting-Long Huang
Xue-Lan Zheng, Yan-Ping Lin, Ting-Long Huang, Department of Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Wan-Ling Li, CT Room, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Author contributions: Zheng XL, and Huang TL designed the research and wrote the first manuscript; Zheng XL, Li WL, Lin YP, and Huang TL contributed to conceiving the research and analyzing data, conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Supported by 2022 Fujian Medical University Qihang Fund General Project Plan, No. 2022QH1120.
Institutional review board statement: This study was approved by the Ethic Committee of The Second Affiliated Hospital of Fujian Medical University. Fuyi Fuer Ethics Review No. (322).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting-Long Huang, Doctor, Staff Physician, Department of Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Licheng District, Quanzhou 362000, Fujian Province, China. htl1203@163.com
Received: October 30, 2023
Peer-review started: October 30, 2023
First decision: November 8, 2023
Revised: December 6, 2023
Accepted: December 18, 2023
Article in press: December 18, 2023
Published online: January 27, 2024
Abstract
BACKGROUND

Severe acute pancreatitis (SAP), a condition with rapid onset, critical condition and unsatisfactory prognosis, poses a certain threat to human health, warranting optimization of relevant treatment plans to improve treatment efficacy.

AIM

To evaluate the efficacy and safety of computerized tomography-guided therapeutic percutaneous puncture catheter drainage (CT-TPPCD) combined with somatostatin (SS) in the treatment of SAP.

METHODS

Forty-two SAP patients admitted to The Second Affiliated Hospital of Fujian Medical University from June 2020 to June 2023 were selected. On the basis of routine treatment, 20 patients received SS therapy (control group) and 22 patients were given CT-TPPCD plus SS intervention (research group). The efficacy, safety (pancreatic fistula, intra-abdominal hemorrhage, sepsis, and organ dysfunction syndrome), abdominal bloating and pain relief time, bowel recovery time, hospital stay, inflammatory indicators (C-reactive protein, interleukin-6, and procalcitonin), and Acute Physiology and Chronic Health Evaluation (APACHE) II score of both groups were evaluated for comparison.

RESULTS

Compared with the control group, the research group had a markedly higher total effective rate, faster abdominal bloating and pain relief and bowel recovery, shorter hospital length of stay, fewer complications, and lower posttreatment inflammatory indices and APACHE-II scores.

CONCLUSION

CT-TPPCD in combination with SS is effective for SAP patients, which can reduce complications, accelerate symptom resolution, inhibit inflammation, and improve patient condition, with promising prospects for clinical promotion.

Keywords: Computerized tomography guidance, Therapeutic percutaneous puncture catheter drainage, Somatostatin, Severe acute pancreatitis, Efficacy and safety

Core Tip: Severe acute pancreatitis (SAP) is a severe acute manifestation of pancreatitis, which may lead to disease deterioration due to local and systemic infections. Therefore, an effective and safe intervention method is urgently needed to optimize the management of SAP patients. This study suggests that computerized tomography-guided therapeutic percutaneous puncture catheter drainage combined with somatostatin for SAP patients has high clinical efficacy and safety, providing a novel option for the clinical management optimization of such patients.