Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2023; 15(9): 1995-2002
Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.1995
Clinical significance of serum oxidative stress and serum uric acid levels before surgery for hepatitis B-related liver cancer
Jin-Xia Hou, Yu-Bin Wang, Jing Wu, Guo-sheng Ding, Yang Wu, Lian-Hua Wei, Fang Wang, Zhe-Mei Zhang
Jin-Xia Hou, Yu-Bin Wang, Jing Wu, Guo-sheng Ding, Yang Wu, Lian-Hua Wei, Fang Wang, Zhe-Mei Zhang, Department of Clinical Laboratory, Gansu Provincial Hospital, Gansu Provincial Clinical Research Center for Laboratory Medicine, Lanzhou 730000, Gansu Province, China
Author contributions: Hou JX contributed to manuscript drafting and revision; Wang YB contributed to study design and data analysis; Hou JX and Wang YB contributed equally to this work and are co-first authors; Zhang ZM provided guiding support; Wu J, Ding GS, and Wu Y collected the data; Wei LH and Wang F sorted the data; all authors have read and approved the final manuscript.
Supported by the Gansu Health Industry Research Plan Project, No. GSWSKY-2019-16; and Lanzhou Science and Technology Development Plan Project, No. 2019-ZD-101.
Institutional review board statement: The study was reviewed and approved by the Gansu Provincial Hospital (Approval No. 2023-288).
Informed consent statement: All study participants or their legal guardian provided informed written consent regarding personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Data for this study can be obtained from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhe-Mei Zhang, MBBS, Associate Chief Physician, Department of Clinical Laboratory, Gansu Provincial Hospital, Gansu Provincial Clinical Research Center for Laboratory Medicine, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. zhangzm1122@126.com
Received: June 6, 2023
Peer-review started: June 6, 2023
First decision: June 21, 2023
Revised: June 30, 2023
Accepted: July 26, 2023
Article in press: July 26, 2023
Published online: September 27, 2023
Processing time: 108 Days and 2.3 Hours
ARTICLE HIGHLIGHTS
Research background

Liver cancer is one of the most common malignant tumors in China and is associated with high morbidity and mortality rates, which seriously threaten the health and life of Chinese residents. The prognosis following conventional hepatectomy is not ideal, with a recurrence rate of up to 70%.

Research motivation

The purpose of this study was to analyze the correlation between preoperative serum oxidative stress level and serum uric acid (UA), and prognosis in patients with hepatitis B-related liver cancer. This relationship was determined to identify simple and effective evaluation indicators for the assessment of disease condition and prognosis, and to provide data support for clinical improvement of treatment.

Research objectives

To explore the correlation between serum oxidative stress level and serum UA, and prognosis before hepatitis B-related liver cancer recurrence. It was found that serum oxidative stress level and serum UA before hepatitis B-related liver cancer were closely related to prognosis, which is helpful for clinicians to more effectively evaluate prognosis, recurrence and to guide treatment decision-making.

Research methods

The analysis methods used in this study involved a logistic regression model, Pearson analysis, Spearman analysis, and a receiver operating characteristic (ROC) curve, and the analysis target was the correlation between serum oxidative stress level, serum UA, and recurrence of hepatitis B-related liver cancer. The analysis of different research data layer by layer was rigorous and scientific.

Research results

This study found that superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and UA were all risk factors for postoperative recurrence in patients with hepatitis B-related liver cancer. Serum UA was positively correlated with MDA and negatively correlated with GSH. MDA and UA can predict the prognosis of patients with hepatitis B-related liver cancer. However, we could not determine the specific mechanism of the effect of these four indicators on postoperative recurrence in patients with hepatitis B-related liver cancer.

Research conclusions

This study found that SOD, GSH, MDA, and UA were all risk factors for postoperative recurrence in patients with hepatitis B-related liver cancer. Furthermore, ROC curve analysis showed that only MDA and UA predicted an AUC above 0.5, which was different to previous studies.

Research perspectives

Future research should include a larger sample and prospectively focus on the specific mechanism of oxidative stress level and UA level on the prognosis of hepatitis B-related liver cancer.