Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.1995
Peer-review started: June 6, 2023
First decision: June 21, 2023
Revised: June 30, 2023
Accepted: July 26, 2023
Article in press: July 26, 2023
Published online: September 27, 2023
Processing time: 108 Days and 2.3 Hours
The incidence and mortality of liver cancer are among the highest of all malignant tumors in China. The high recurrence rate after conventional hepatectomy is worrying. There is a lack of effective prognostic indicators for liver cancer.
To explore the clinical significance of preoperative serum oxidative stress and serum uric acid (UA) levels in hepatitis B-related liver cancer.
The medical records of 110 hepatitis B-related liver cancer patients who under
Compared with the non-recurrence group, the levels of superoxide dismutase (SOD) and glutathione (GSH) in the recurrence group were lower and the levels of malondialdehyde (MDA) and UA were higher (all P < 0.05). UA, SOD, MDA, and GSH were risk factors for postoperative recurrence in hepatitis B-related liver cancer patients (P < 0.05). UA was positively correlated with MDA (r = 0.395, P < 0.001) and negatively correlated with GSH (r = -0.204, P = 0.032). The area under the receiver operating characteristic curve (AUC) of SOD, MDA, GSH, and UA in predicting the prognosis was 0.276, 0.910, 0.199, and 0.784, respectively (all P < 0.001).
The preoperative serum SOD, GSH, MDA, and UA levels had significant predictive effects on postoperative recurrence of hepatitis B-related liver cancer.
Core Tip: Hepatitis B-related liver cancer is characterized by high morbidity and mortality. Conventional surgery results in a poor prognosis and a high recurrence rate of liver cancer. In this study, we analyzed the clinical data of 110 patients with hepatitis B-related liver cancer who underwent hepatectomy and determined recurrence within three years after surgery. The correlation between preoperative serum oxidative stress level and serum uric acid, and recurrence of hepatitis B-related liver cancer was assessed. These findings provide a breakthrough in prognostic evaluation indicators of liver cancer.