Hou JX, Wang YB, Wu J, Ding GS, Wu Y, Wei LH, Wang F, Zhang ZM. Clinical significance of serum oxidative stress and serum uric acid levels before surgery for hepatitis B-related liver cancer. World J Gastrointest Surg 2023; 15(9): 1995-2002 [PMID: 37901740 DOI: 10.4240/wjgs.v15.i9.1995]
Corresponding Author of This Article
Zhe-Mei Zhang, MBBS, Associate Chief Physician, Department of Clinical Laboratory, Gansu Provincial Hospital, Gansu Provincial Clinical Research Center for Laboratory Medicine, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. zhangzm1122@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jin-Xia Hou, Yu-Bin Wang, Jing Wu, Guo-sheng Ding, Yang Wu, Lian-Hua Wei, Fang Wang, Zhe-Mei Zhang, Department of Clinical Laboratory, Gansu Provincial Hospital, Gansu Provincial Clinical Research Center for Laboratory Medicine, Lanzhou 730000, Gansu Province, China
Author contributions: Hou JX contributed to manuscript drafting and revision; Wang YB contributed to study design and data analysis; Hou JX and Wang YB contributed equally to this work and are co-first authors; Zhang ZM provided guiding support; Wu J, Ding GS, and Wu Y collected the data; Wei LH and Wang F sorted the data; all authors have read and approved the final manuscript.
Supported bythe Gansu Health Industry Research Plan Project, No. GSWSKY-2019-16; and Lanzhou Science and Technology Development Plan Project, No. 2019-ZD-101.
Institutional review board statement: The study was reviewed and approved by the Gansu Provincial Hospital (Approval No. 2023-288).
Informed consent statement: All study participants or their legal guardian provided informed written consent regarding personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Data for this study can be obtained from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhe-Mei Zhang, MBBS, Associate Chief Physician, Department of Clinical Laboratory, Gansu Provincial Hospital, Gansu Provincial Clinical Research Center for Laboratory Medicine, No. 204 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. zhangzm1122@126.com
Received: June 6, 2023 Peer-review started: June 6, 2023 First decision: June 21, 2023 Revised: June 30, 2023 Accepted: July 26, 2023 Article in press: July 26, 2023 Published online: September 27, 2023 Processing time: 108 Days and 2.3 Hours
Abstract
BACKGROUND
The incidence and mortality of liver cancer are among the highest of all malignant tumors in China. The high recurrence rate after conventional hepatectomy is worrying. There is a lack of effective prognostic indicators for liver cancer.
AIM
To explore the clinical significance of preoperative serum oxidative stress and serum uric acid (UA) levels in hepatitis B-related liver cancer.
METHODS
The medical records of 110 hepatitis B-related liver cancer patients who underwent hepatectomy in Gansu Provincial Hospital were retrospectively analyzed. Recurrence in patients within 3 years after surgery was determined. The logistic regression model and Pearson or Spearman correlation were used to analyze the correlation between oxidative stress level and UA, and the recurrence of hepatitis B-related liver cancer.
RESULTS
Compared with the non-recurrence group, the levels of superoxide dismutase (SOD) and glutathione (GSH) in the recurrence group were lower and the levels of malondialdehyde (MDA) and UA were higher (all P < 0.05). UA, SOD, MDA, and GSH were risk factors for postoperative recurrence in hepatitis B-related liver cancer patients (P < 0.05). UA was positively correlated with MDA (r = 0.395, P < 0.001) and negatively correlated with GSH (r = -0.204, P = 0.032). The area under the receiver operating characteristic curve (AUC) of SOD, MDA, GSH, and UA in predicting the prognosis was 0.276, 0.910, 0.199, and 0.784, respectively (all P < 0.001).
CONCLUSION
The preoperative serum SOD, GSH, MDA, and UA levels had significant predictive effects on postoperative recurrence of hepatitis B-related liver cancer.
Core Tip: Hepatitis B-related liver cancer is characterized by high morbidity and mortality. Conventional surgery results in a poor prognosis and a high recurrence rate of liver cancer. In this study, we analyzed the clinical data of 110 patients with hepatitis B-related liver cancer who underwent hepatectomy and determined recurrence within three years after surgery. The correlation between preoperative serum oxidative stress level and serum uric acid, and recurrence of hepatitis B-related liver cancer was assessed. These findings provide a breakthrough in prognostic evaluation indicators of liver cancer.
