Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2513
Peer-review started: September 19, 2023
First decision: October 8, 2023
Revised: October 26, 2023
Accepted: November 3, 2023
Article in press: November 3, 2023
Published online: November 27, 2023
Processing time: 69 Days and 1.9 Hours
Gastric cancer (GC) is a commonly observed malignancy and the main cause of cancer-related deaths worldwide. However, the accuracy of traditional computed tomography (CT) in preoperative staging remains controversial. CD34 is an endothelial cell marker that can help evaluate microvessel density (MVD) and angiogenesis in tumors. The combination of CD34 expression and dynamic three-phase enhanced CT can improve the accuracy of preoperative staging.
Early diagnosis, accurate staging, and detection of lymph node metastasis are crucial for the prognosis and development of treatment plans for patients with GC. This study aimed to evaluate the value of CD34 expression combined with dynamic three-phase enhanced CT in the preoperative staging and invasion evaluation of GC to explore new methods to improve the accuracy of preoperative evaluation and postoperative treatment.
The main goal of this study was to evaluate the value of CD34 expression combined with dynamic three-phase enhanced CT in the preoperative staging and invasion evaluation of GC. According to a study of 106 patients with GC, CD34-marked MVD positively correlated with the T and N stages, and CD34 expression combined with CT showed high sensitivity in GC staging. Tumor diameter, T stage, degree of differentiation, and CD34-marked MVD were independent risk factors for lymph node metastasis. The results of this study provide a new method for the preoperative staging and treatment planning of GC. The combination of CD34 expression and CT can improve staging accuracy and contribute to the evaluation of infiltration.
In this study, the results of CD34 detection and dynamic three-phase enhanced CT scanning in 106 patients with GC were compared and analyzed with postoperative pathological results. The independent factors of preoperative lymph node metastasis were analyzed using multivariate logistic regression. The novelty of this study is that CD34 expression was combined with dynamic three-phase enhanced CT for diagnosis, and the accuracy of preoperative staging and invasion assessment of GC was improved through a comprehensive analysis of the two types of results. In addition, independent risk factors were determined using multivariate logistic regression analysis, which provided a scientific basis for clinical decision-making.
According to the results of this study, the combination of CD34 expression and dynamic three-phase enhanced CT showed a high sensitivity for preoperative staging of GC. Additionally, tumor diameter, T stage, degree of differentiation, and CD34-marked MVD were identified as independent risk factors for lymph node metastasis. Therefore, the combination of CD34 expression and dynamic three-phase-enhanced CT scanning can improve the accuracy of GC staging and help evaluate invasion. Although CD34 expression and dynamic three-phase enhanced CT scanning showed high sensitivity in this study, their specificity and accuracy require further evaluation.
This study highlights the critical role of angiogenesis in the development of GC and provides new theories and methods to improve preoperative staging and invasion evaluation of GC by combining CD34 expression with dynamic three-phase enhanced CT scanning. These new theories and methods will help deepen the understanding of the developmental mechanism of GC, guide clinical decision-making, and improve prognosis.
Further research should verify and expand our research results by exploring new biomarkers and imaging technologies, studying the mechanisms of GC development, and developing individualized treatment strategies. These efforts will further improve the diagnosis and treatment of GC, improving the prognosis and quality of life of patients.