Zhu JW, Gong LZ, Wang QW. Serum tumor markers (carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, carbohydrate antigen 24-2, ferritin) and gastric cancer prognosis correlation. World J Gastrointest Surg 2024; 16(9): 2808-2814 [DOI: 10.4240/wjgs.v16.i9.2808]
Corresponding Author of This Article
Qian-Wen Wang, Technologist in charge, Bachelor’s degree, Department of Clinical Laboratory, Huangshi Central Hospital, (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory, No. 293 Hospital Street, Xisai District, Huangshi 435000, Hubei Province, China. wangqianwen0108@163.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2024; 16(9): 2808-2814 Published online Sep 27, 2024. doi: 10.4240/wjgs.v16.i9.2808
Serum tumor markers (carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, carbohydrate antigen 24-2, ferritin) and gastric cancer prognosis correlation
Jie-Wen Zhu, Ling-Zhen Gong, Qian-Wen Wang
Jie-Wen Zhu, Ling-Zhen Gong, Qian-Wen Wang, Department of Clinical Laboratory, Huangshi Central Hospital (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory, Huangshi 435000, Hubei Province, China
Co-first authors: Jie-Wen Zhu and Ling-Zhen Gong.
Author contributions: Zhu JW, Gong LZ, Wang QW contributed equally to this work; Zhu JW, Gong LZ designed the research study, performed the primary literature and data extraction, analyzed the data and wrote the manuscript; Zhu JW, Gong LZ, Wang QW were responsible for revising the manuscript for important intellectual content; All authors read and approved the final version.
Institutional review board statement: The study was reviewed and approved by the Huangshi central hospital Institutional Review Board [Approval No. 2021(90)].
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at wangqianwen0108@163.com. Participants gave informed consent for data sharing.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qian-Wen Wang, Technologist in charge, Bachelor’s degree, Department of Clinical Laboratory, Huangshi Central Hospital, (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory, No. 293 Hospital Street, Xisai District, Huangshi 435000, Hubei Province, China. wangqianwen0108@163.com
Received: May 10, 2024 Revised: July 2, 2024 Accepted: July 22, 2024 Published online: September 27, 2024 Processing time: 130 Days and 13.5 Hours
Abstract
BACKGROUND
Gastric cancer is a kind of malignant tumor which is prevalent all over the world. Although some progress has been made in the treatment of gastric cancer, its prognosis is still not optimistic, so it is of great significance to find reliable prognostic indicators to guide the treatment and management of patients with gastric cancer.
AIM
To explore the relationship between serum levels of five biomarkers [carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA72-4, CA24-2, and ferritin] and prognosis in patients with gastric cancer.
METHODS
This study included 200 patients with gastric adenocarcinoma, and conducted an in-depth analysis of their baseline characteristics, relationship between tumor markers and staging, and prognosis. The study found that CA19-9 has a significant correlation with tumor stage, the average levels of CA24-2, CEA, CA72-4 and ferritin were slightly increased disregarding the stage of tumor. Survival analysis showed that increases in CEA, CA19-9, CA24-2, and ferritin were all associated with shortened overall survival of patients. Further multivariate analysis revealed that elevated serum CA72-4 levels were an independent adverse prognostic factor.
RESULTS
This study reveals that there is a significant correlation between the expression levels of serum tumor markers CEA, CA19-9, CA72-4, CA24-2 and ferritin in patients with gastric cancer and prognosis, and can be used as important indicators for prognostic evaluation of gastric cancer. In particular, markers that appear abnormally elevated initially may help identify gastric cancer patients with poor prognosis.
CONCLUSION
Serum CEA and CA19-9 play an important role in the prognosis assessment of gastric cancer, and are effective tools to guide clinical practice and optimize individualized treatment strategies for gastric cancer patients.
Core Tip: In this study, the aim is to establish a scientific basis for tailoring personalized treatment strategies and evaluating the prognosis of individuals affected by gastric cancer. This study demonstrates a significant association between the expression levels of serum tumor markers carcinoembryonic antigen, carbohydrate antigen (CA) 19-9, CA72-4, CA24-2 and ferritin in patients with gastric cancer and their prognosis. These markers can serve as important indicators for prognostic evaluation of gastric cancer. Notably, abnormally elevated initial marker levels may aid in identifying gastric cancer patients with poor prognosis.
