Observational Study
Copyright ©The Author(s) 2023.
World J Diabetes. Mar 15, 2023; 14(3): 290-298
Published online Mar 15, 2023. doi: 10.4239/wjd.v14.i3.290
Table 1 Clinical and biochemical characteristics of patients with type 2 diabetes
Variable
Patients with T2DM (2013)
Patients with T2DM (2018)
P value
n = 47
n = 104
Sex [H (%)]26 (55.3)34 (32.7)0.009
Age (yr)a12.96 ± 1.914.6 ± 1.90.000
Weight (kg)62.6 ± 20.462.8 ± 19.40.956
Height (cm)157.5 ± 14.2156.9 ± 11.90.773
BMI (kg/m2)a25.3 ± 5.324.4 ± 6.70.170
Waist (cm)a84.7 ± 14.284.5 ± 19.20.905
Cholesterol total (mg/dL)163.4 ± 33.1172.5 ± 39.80.172
HDL-C (mg/dL)a40.7 ± 12.144.1 ± 8.60.087
LDL-C (mg/dL)a100.0 ± 25.395.9 ± 31.30.436
Triglycerides (mg/dL)a136.7 ± 92.0147.7 ± 64.90.412
AST (U/L)b22.0 (11-143)23.0 (11-89)0.403
ALT (U/L)b43.0 (23-139)36.0 (11-79)0.005
Fasting glucose (mg/dL)a150.9 ± 88.1189.0 ± 109.20.038
HbA1c (%)a10.5 ± 3.98.9 ± 2.80.069
Fasting insulin (mUI/mL)b11.2 (2-71)11.2 (2-80)0.902
C-peptide (ng/dL)b2.0 (0.09-8.0)1.5 (0.1-8.5)0.014
SBP (mmHg)b95.8 (70-130)110 (90-150)0.004
DBP (mmHg)b62.8 (48-85)70.0 (60-90)0.005
HOMA-βb135.9 (23-160.9)50.2 (16-145)0.183
Table 2 Family member and perinatal antecedents in the two study groups, n (%)
VariablePatients with T2DM (2013)
Patients with T2DM (2018)
P value
n = 47
n = 104
History of T2DM, in relatives of 1° and 2° [n (%)]24 (51.1)79 (75.9)0.002
Antecedent of obesity in relatives of 1° and 2° [n (%)]31 (65.9)84 (80.7)0.048
Antecedent of DM [n (%)]7 (14.9)9 (8.7)0.249
Weight at birth (kg)3.31 ± 0.663.03 ± 0.440.005
Socioeconomic statusa,b
Upper 5 (10.6)6 (5.8)
Upper-middle6 (12.8)6 (5.8)
Middle6 (12.8)18 (17.3)0.023
Lower-middle16 (34)18 (17.3)
Upper-Lower10 (21.3)28 (26.9)
Lower4 (8.5)28 (26.9)
Comorbidities
Hypercholesterolemia [n (%)]22 (46.8)29 (27.9)0.023
Hypertriglyceridemia27 (57.4)78 (75.0)0.030
Hypoalphalipoproteinemia19 (40.4)16 (15.4)0.001
Hepatic steatosis6 (12.8)22 (21.2)0.219
Arterial hypertension5 (10.6)22 (22.3)0.021