Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations

doi:10.4239/wjd.v14.i12.1766

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 12

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (1238)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-7) series, Tables (1-4) series.

Item

Count

PDF

WORD

HTML

582

Figures (1-7)

Tables (1-4)

103

Sum=847

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

119

Download

201

Sum=320

Dec 15, 2023 (publication date) through May 15, 2024

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Diabetes. Dec 15, 2023; 14(12): 1766-1783
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1766

Table 1 Subject demographics and biochemical blood indices

Parameter	Han population			Dai population
Parameter	Healthy adults, n = 8	T2DM patients, n = 12	Healthy children, n = 15	Healthy adults, n = 10	T2DM patients, n = 12	Healthy children, n = 10
Sex as male/female	3/5	8/4	7/8	5/5	9/3	4/6
Age in yr	50.63 ± 5.85	55.27 ± 11.76	5.00 ± 2.10¹	45.70 ± 14.66²	55.92 ± 9.07	5.50 ± 1.18³
FBG in mmol/L	4.85 ± 0.38	9.98 ± 5.89¹	3.23 ± 0.99	5.62 ± 1.36	7.74 ± 2.39³	4.52 ± 0.29
HbA1c as %	5.55 ± 0.24	8.55 ± 2.59¹	5.23 ± 0.15	5.58 ± 0.19	7.24 ± 0.77³^,⁴	5.19 ± 0.35
TG in mmol/L	1.90 ± 0.63	2.22 ± 1.54	0.97 ± 0.24¹	3.90 ± 4.10²	2.48 ± 1.91	1.12 ± 0.45³
TC in mmol/L	5.15 ± 0.61	3.76 ± 1.45¹	4.01 ± 0.88	5.51 ± 1.04	4.85 ± 1.26⁴	3.91 ± 0.57³
HDL-C in mmol/L	1.28 ± 0.28	0.97 ± 0.22¹	1.48 ± 0.34	1.23 ± 0.28	1.26 ± 0.40	1.39 ± 0.42
LDL-C in mmol/L	3.12 ± 0.64	1.82 ± 0.71¹	2.16 ± 0.63¹	2.98 ± 1.23	2.75 ± 1.05⁴	2.16 ± 0.38
APO-A1 in g/L	1.75 ± 0.27	1.30 ± 0.30¹	1.75 ± 0.36	1.83 ± 0.23	1.74 ± 0.37⁴	1.61 ± 0.36
APO-B in g/L	1.04 ± 0.15	0.68 ± 0.18¹	0.72 ± 0.19¹	0.98 ± 0.24	0.94 ± 0.29	0.66 ± 0.09³
WBC as 10⁹/L	6.06 ± 1.44	6.41 ± 1.87	6.95 ± 1.11	6.79 ± 1.43	7.07 ± 2.09	8.32 ± 2.38
RBC as 10¹²/L	5.19 ± 0.66	4.82 ± 0.57	4.89 ± 0.27	5.09 ± 0.65	5.05 ± 0.57	4.90 ± 0.42
TBil in μmol/L	6.84 ± 1.59	14.19 ± 9.35¹	6.07 ± 4.48	8.71 ± 5.08²	6.19 ± 1.98⁴	5.74 ± 2.38
DBil in μmol/L	3.84 ± 0.79	6.31 ± 2.92¹	2.92 ± 2.34	3.96 ± 2.05	3.35 ± 1.02⁴	3.13 ± 1.40
IBil in μmol/L	3.00 ± 0.85	7.88 ± 6.51¹	3.15 ± 2.28	4.75 ± 3.05²	2.84 ± 1.34⁴	2.61 ± 1.41³
ALT in U/L	22.50 ± 11.33	31.36 ± 26.34	15.80 ± 14.85	25.50 ± 15.68	26.10 ± 17.22	13.70 ± 14.96
AST in U/L	21.13 ± 4.58	27.36 ± 25.61	31.50 ± 7.18¹	23.26 ± 8.71	23.14 ± 8.64	27.40 ± 6.45
GGT in U/L	34.75 ± 24.40	51.82 ± 90.65	9.67 ± 2.94¹	70.40 ± 66.34²	38.67 ± 22.80⁴	13.50 ± 8.15³
BUN in mmol/L	5.63 ± 1.40	4.59 ± 1.70	3.68 ± 0.82¹	5.12 ± 1.51	5.23 ± 2.18	3.75 ± 0.91
Cr in μmol/L	70.38 ± 8.75	69.55 ± 20.92	32.17 ± 7.60¹	68.20 ± 17.69	85.50 ± 30.21	32.00 ± 4.00³
Hcy in μmol/L	15.63 ± 3.45	12.35 ± 1.55¹	14.20 ± 3.12	13.59 ± 3.57	16.69 ± 3.47⁴	11.55 ± 1.53⁵
hs-CRP in mg/L	1.85 ± 3.35	3.46 ± 5.23	2.84 ± 6.66⁵	1.84 ± 1.57	1.83 ± 1.47⁴	0.47 ± 0.50³

¹P < 0.05 vs healthy adults in the Han population.

²P < 0.05, healthy adults in the Han population vs healthy adults in the Dai population.

³P < 0.05 vs healthy adults in the Dai population.

⁴P < 0.05, adult type 2 diabetes mellitus patients in the Han population vs adult type 2 diabetes mellitus patients in the Dai population.

⁵P < 0.05, healthy children in the Han population vs healthy children in the Dai population.

ALT: Alanine transaminase; APO: Apolipoprotein; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; Cr: Creatinine; DBil: Direct bilirubin; FBG: Fasting blood glucose; GGT: Gamma glutamyl transferase; HbA1c: Hemoglobin A1c; Hcy: Homocysteine; HDL-C: High density lipoprotein cholesterol; hs-CRP: Hypersensitive C-reactive protein; IBil: Indirect bilirubin; LDL-C: Low density lipoprotein cholesterol; RBC: Red blood cell; T2DM: Type 2 diabetes mellitus; TBil: Total bilirubin; TC: Total cholesterol; TG: Triglyceride; WBC: White blood cell.

Table 2 Significantly increased bacteria in type 2 diabetes mellitus patients in the Han population

Taxa	Abundance, T2DM patients vs healthy adults	LDA score	P value
Bacteria. Bacteroidetes	5.353	4.939	0.037
Bacteria. Bacteroidetes. Bacteroidia. Bacteroidales	5.353	4.939	0.037
Bacteria. Firmicutes. Clostridia. Clostridiales. Veillonellaceae. Megamonas	4.347	3.760	0.045
Bacteria. Bacteroidetes. Bacteroidia	5.353	4.939	0.037

LDA: Linear discriminant analysis; T2DM: Type 2 diabetes mellitus.

Table 3 Significantly increased gut microbiota in type 2 diabetes mellitus patients in the Dai population

Taxa	Abundance, T2DM patients vs healthy adults	LDA score	P value
Bacteria. Proteobacteria. Gammaproteobacteria. Pseudomonadales. Moraxellaceae. Acinetobacter	2.047	2.754	0.004
Bacteria. Proteobacteria. Gammaproteobacteria. Enterobacteriales. Enterobacteriaceae. Shigella	4.711	4.288	0.021
Bacteria. Proteobacteria. Deltaproteobacteria	3.199	2.764	0.044

LDA: Linear discriminant analysis; T2DM: Type 2 diabetes mellitus.

Table 4 Differential gut microbiota observed in the Han population vs Dai population

Differential gut microbiota	Healthy children	Healthy adults	T2DM patients
Han population
d__Bacteria.p__Firmicutes.c__Clostridia.o__Clostridiales.f__Lachnospiraceae.g__Coprococcus.s__unidentified_Coprococcus	0.542^a	0.259^a	0.461
d__Bacteria.p__Firmicutes.c__Bacilli.o__Lactobacillales.f__Streptococcaceae.g__Streptococcus.s__unclassified_Streptococcus	0.000^a	0.800^a	1.000
d__Bacteria.p__Firmicutes.c__Clostridia.o__Clostridiales.f__Lachnospiraceae.g__Coprococcus	0.521^a	0.286^a	0.475
d__Bacteria.p__Firmicutes.c__Bacilli.o__Lactobacillales.f__Streptococcaceae.g__Lactococcus	0.009^a	0.019^a	0.083
Dai population
d__Bacteria.p__Proteobacteria.c__Alphaproteobacteria.o__Rhizobiales	4.840^a	1.159^a	1.636
d__Bacteria.p__Firmicutes.c__Clostridia.o__Clostridiales.f__Veillonellaceae.g__unclassified_Veillonellaceae	8.800^a	12.000^a	1.688

^aP < 0.05 Han population vs Dai population.

T2DM: Type 2 diabetes mellitus.

Citation: Tang LT, Feng L, Cao HY, Shi R, Luo BB, Zhang YB, Liu YM, Zhang J, Li SY. Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations. World J Diabetes 2023; 14(12): 1766-1783
URL: https://www.wjgnet.com/1948-9358/full/v14/i12/1766.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i12.1766