Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1766
Peer-review started: October 7, 2023
First decision: October 17, 2023
Revised: October 24, 2023
Accepted: November 17, 2023
Article in press: November 17, 2023
Published online: December 15, 2023
Processing time: 68 Days and 7.6 Hours
The global prevalence of type 2 diabetes mellitus (T2DM) is increasing. T2DM is associated with alterations of the gut microbiota, which can be affected by age, illness, and genetics. Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations. However, the specific gut microbiota differences between the two populations have not been elucidated.
To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han populations.
A total of 35 subjects of the Han population (including 15 healthy children, 8 adult healthy controls, and 12 adult T2DM patients) and 32 subjects of the Dai popu
No significant difference in alpha diversity was observed between healthy children and adults. The diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Han population with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, this difference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteria in the Dai population and decreases in Firmicutes in both the Han and Dai population were observed in T2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that the gut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM patients. Four bacteria were consistently increased and two consistently decreased in the Han population compared to the Dai population.
Differences in gut microbiota were found between the Han and Dai populations. A significant increase in Bacteroidetes was related to the occurrence of T2DM in the Han population, while a significant increase in Proteobacteria was related to the occurrence of T2DM in the Dai population.
Core Tip: This study revealed that gut microbiota in the Han population is significantly different from the Dai population in healthy children, healthy adults, and patients with type 2 diabetes mellitus (T2DM). There was a significant difference in gut microbiota between healthy children and healthy adults in the Han population, but the difference was less in the Dai population. A significant increase in Bacteroidetes was observed in T2DM patients in the Han population, while a significant increase in Proteobacteria was observed in T2DM patients in the Dai population when compared to healthy controls.