Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2025; 16(4): 104241
Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.104241
Plantamajoside mitigates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in type 2 diabetes via DNAJC1 upregulation
Md Abdul Alim Al-Bari, Fabian Davamani, Payal Bhatnagar, Nabil Eid
Md Abdul Alim Al-Bari, Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh
Fabian Davamani, Division of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur 57000, Malaysia
Payal Bhatnagar, Department of Pharmaceutical Technology, School of Pharmacy, IMU University, Kuala Lumpur 57000, Malaysia
Nabil Eid, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia
Author contributions: Al-Bari MAA and Davamani F wrote the manuscript; Al-Bari MAA and Bhatnagar P designed the figures; Eid N, wrote, edited and approved the final draft of the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors have nothing to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nabil Eid, MD, PhD, Assistant Professor, Associate Professor, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Received: December 17, 2024
Revised: January 14, 2025
Accepted: January 22, 2025
Published online: April 15, 2025
Processing time: 76 Days and 8 Hours
Core Tip

Core Tip: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with no known cure, representing significant challenges in both early diagnosis and treatment. Wang et al explored the effects of Plantamajoside (PMS) on pancreatic β-cell function using in vitro and in vivo animal models of T2DM. The authors determined the protective effect of PMS on MIN6 insulinoma cells and diabetic mice via upregulation of DNAJC1, suppressing endoplasmic reticulum stress and apoptosis of pancreatic β-cells. This discovery suggests promising advances in the clinical management of T2DM patients; however, transforming these results into clinical interventions demands further mechanistic elucidation and verification.