Al-Bari MAA, Davamani F, Bhatnagar P, Eid N. Plantamajoside mitigates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in type 2 diabetes via DNAJC1 upregulation. World J Diabetes 2025; 16(4): 104241 [DOI: 10.4239/wjd.v16.i4.104241]
Corresponding Author of This Article
Nabil Eid, MD, PhD, Assistant Professor, Associate Professor, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Apr 15, 2025; 16(4): 104241 Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.104241
Plantamajoside mitigates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in type 2 diabetes via DNAJC1 upregulation
Md Abdul Alim Al-Bari, Fabian Davamani, Payal Bhatnagar, Nabil Eid
Md Abdul Alim Al-Bari, Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh
Fabian Davamani, Division of Applied Biomedical Sciences and Biotechnology, School of Health Sciences, IMU University, Kuala Lumpur 57000, Malaysia
Payal Bhatnagar, Department of Pharmaceutical Technology, School of Pharmacy, IMU University, Kuala Lumpur 57000, Malaysia
Nabil Eid, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia
Author contributions: Al-Bari MAA and Davamani F wrote the manuscript; Al-Bari MAA and Bhatnagar P designed the figures; Eid N, wrote, edited and approved the final draft of the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors have nothing to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nabil Eid, MD, PhD, Assistant Professor, Associate Professor, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Received: December 17, 2024 Revised: January 14, 2025 Accepted: January 22, 2025 Published online: April 15, 2025 Processing time: 76 Days and 8 Hours
Abstract
Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia and other symptoms, which pose significant challenges to individual health, life expectancy, and public healthcare systems. The escalating global prevalence of diabetes underscores the need for innovative therapeutic interventions. In this article, we critically comment on the study by Wang et al, published in the World Journal of Diabetes, which elucidates the therapeutic potential of Plantamajoside (PMS) in type 2 DM (T2DM) management. The authors provide evidence for the mechanism of action of PMS in T2DM models, demonstrating prevention of endoplasmic reticulum stress and apoptosis of pancreatic β-cells via activation of DNAJC1. This manuscript provides a brief review of the pathogenesis of T2DM, explores the various roles of PMS in disease therapy in addition to the DNAJC-related apoptotic and autophagic functions, critically evaluates the experimental approaches employed by Wang et al, and provides recommendations for advancing future research.
Core Tip: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with no known cure, representing significant challenges in both early diagnosis and treatment. Wang et al explored the effects of Plantamajoside (PMS) on pancreatic β-cell function using in vitro and in vivo animal models of T2DM. The authors determined the protective effect of PMS on MIN6 insulinoma cells and diabetic mice via upregulation of DNAJC1, suppressing endoplasmic reticulum stress and apoptosis of pancreatic β-cells. This discovery suggests promising advances in the clinical management of T2DM patients; however, transforming these results into clinical interventions demands further mechanistic elucidation and verification.
