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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2024; 15(8): 1778-1792
Published online Aug 15, 2024. doi: 10.4239/wjd.v15.i8.1778
Published online Aug 15, 2024. doi: 10.4239/wjd.v15.i8.1778
Mitigating diabetes-related complications: Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats
Mai S Attia, Fadwa Ayman, Mansour H Zahra, Abdel Aziz A Diab, Department of Zoology, Faculty of Science, Zagazig 44519, Egypt
Mohamed S Attia, Department of Pharmaceutics, Faculty of Pharmacy, Zagazig 44519, Egypt
Galal Yahya, Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
Magdi Mohamed Ibrahim Khalil, Department of Biochemistry, Faculty of Medicine, Zagazig 44519, Egypt
Co-first authors: Mai S Attia and Fadwa Ayman.
Author contributions: Attia MaS and Ayman F contributed equally to this experimental study as they are co-first authors of this manuscript. Attia MaS, Ayman F and Diab AA designed the study; Attia MaS and Ayman F conducted the research experiments, Attia MaS and FA performed data collection and statistical analysis; Attia MoS, Ayman F, Attia MaS wrote the original draft; Attia MoS, Ayman F and Yahya G rewrote and revised the manuscript after editing; Diab AA, Zahra MH, Yahya G and Khalil MMI provided supervision; all authors have read and agreed to the published version of the manuscript.
Institutional animal care and use committee statement: The study was reviewed and approved by Institutional Review Board, No. ZU-IACUC/2/F/47/2022.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fadwa Ayman, BSc, Master's Student, Research Assistant, Teaching Assistant, Department of Zoology, Faculty of Science, Faculty of Science Primary Building, Shaibet an Nakareyah, Zagazig 44519, Egypt. fadwaayman@zu.edu.eg
Received: April 6, 2024
Revised: June 30, 2024
Accepted: July 17, 2024
Published online: August 15, 2024
Processing time: 111 Days and 1.7 Hours
Revised: June 30, 2024
Accepted: July 17, 2024
Published online: August 15, 2024
Processing time: 111 Days and 1.7 Hours
Core Tip
Core Tip: Supplementation of cholecalciferol and taurine in conjunction with metformin shows promise in enhancing the management of type 2 diabetes by addressing hyperglycemia and minimizing the risk of associated complications. This combination therapy demonstrates antioxidative, anti-inflammatory, and anti-apoptotic properties, leading to improvements in glucose and insulin levels, Homeostasis Model Assessment of Insulin Resistance, glycated hemoglobin%, lipid profiles, liver function markers, and oxidative stress markers in diabetic rats. The proposed regimen also promotes recovery of pancreatic islet mass, highlighting its potential to mitigate diabetic complications.