Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2024; 15(7): 1551-1561
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1551
Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study
Ke-Ke Tong, Yun-Feng Yu, Xin-Yu Yang, Jing-Yi Wu, Rong Yu, Chuan-Chuan Tan
Ke-Ke Tong, Yun-Feng Yu, Rong Yu, Chuan-Chuan Tan, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
Xin-Yu Yang, School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
Jing-Yi Wu, The Third Hospital, Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Co-first authors: Ke-Ke Tong and Yun-Feng Yu.
Co-corresponding authors: Rong Yu and Chuan-Chuan Tan.
Author contributions: Tong KK and Yu YF conceived and designed the study; Yu YF and Yang XY participated in data processing and statistical analyses; Tong KK, Yu YF, Yang XY, and Wu JY drafted the manuscript; Yu R and Tan CC supervised the review of the study; All authors revised and approved the final manuscript. Tong KK and Yu YF have made equal contributions to this work as co-first authors for two reasons. First, Tong KK and Yu YF made contributions of equal significance throughout the research process. The choice of these researchers as co-first authors acknowledges and respects this equal contribution. Second, the research was a collaborative effort, and co-first authorship accurately reflects the distribution of responsibilities and the substantial time and effort invested in completing the study and the resulting paper. In summary, designating Tong KK and Yu YF as co-first authors is appropriate for our manuscript as it faithfully reflects our team’s collaborative ethos, equal contributions, and diversity. In addition, Tan CC and Yu R have made equal contributions to this work as co-corresponding authors. Their work spanned the entire process, collectively guiding the conception, drafting, revision, and finalization of the manuscript, which is indispensable to the completion of this manuscript.
Supported by the Discipline Construction Project of Hunan University of Chinese Medicine, No. 22JBZ002.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chuan-Chuan Tan, MM, The First Hospital of Hunan University of Chinese Medicine, No. 95 Shaoshan Middle Road, Yuhua District, Changsha 410007, Hunan Province, China. tcc@hnucm.edu.cn
Received: February 28, 2024
Revised: May 2, 2024
Accepted: May 28, 2024
Published online: July 15, 2024
Processing time: 130 Days and 16.5 Hours
Core Tip

Core Tip: Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic beta cells. As research progresses, the potential relationship between T1D and inflammatory bowel disease (IBD) has attracted an increasing amount of attention. The study analyzed the causal relationship between T1D and IBD using Mendelian randomization. Our findings indicate that T1D serves as a potential protective factor against IBD and ulcerative colitis but is independent of Crohn’s disease.