Tong KK, Yu YF, Yang XY, Wu JY, Yu R, Tan CC. Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study. World J Diabetes 2024; 15(7): 1551-1561 [PMID: 39099830 DOI: 10.4239/wjd.v15.i7.1551]
Corresponding Author of This Article
Chuan-Chuan Tan, MM, The First Hospital of Hunan University of Chinese Medicine, No. 95 Shaoshan Middle Road, Yuhua District, Changsha 410007, Hunan Province, China. tcc@hnucm.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical and Translational Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jul 15, 2024; 15(7): 1551-1561 Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1551
Does type 1 diabetes serve as a protective factor against inflammatory bowel disease: A Mendelian randomization study
Ke-Ke Tong, Yun-Feng Yu, Xin-Yu Yang, Jing-Yi Wu, Rong Yu, Chuan-Chuan Tan
Ke-Ke Tong, Yun-Feng Yu, Rong Yu, Chuan-Chuan Tan, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China
Xin-Yu Yang, School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
Jing-Yi Wu, The Third Hospital, Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Co-first authors: Ke-Ke Tong and Yun-Feng Yu.
Co-corresponding authors: Rong Yu and Chuan-Chuan Tan.
Author contributions: Tong KK and Yu YF conceived and designed the study; Yu YF and Yang XY participated in data processing and statistical analyses; Tong KK, Yu YF, Yang XY, and Wu JY drafted the manuscript; Yu R and Tan CC supervised the review of the study; All authors revised and approved the final manuscript. Tong KK and Yu YF have made equal contributions to this work as co-first authors for two reasons. First, Tong KK and Yu YF made contributions of equal significance throughout the research process. The choice of these researchers as co-first authors acknowledges and respects this equal contribution. Second, the research was a collaborative effort, and co-first authorship accurately reflects the distribution of responsibilities and the substantial time and effort invested in completing the study and the resulting paper. In summary, designating Tong KK and Yu YF as co-first authors is appropriate for our manuscript as it faithfully reflects our team’s collaborative ethos, equal contributions, and diversity. In addition, Tan CC and Yu R have made equal contributions to this work as co-corresponding authors. Their work spanned the entire process, collectively guiding the conception, drafting, revision, and finalization of the manuscript, which is indispensable to the completion of this manuscript.
Supported bythe Discipline Construction Project of Hunan University of Chinese Medicine, No. 22JBZ002.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chuan-Chuan Tan, MM, The First Hospital of Hunan University of Chinese Medicine, No. 95 Shaoshan Middle Road, Yuhua District, Changsha 410007, Hunan Province, China. tcc@hnucm.edu.cn
Received: February 28, 2024 Revised: May 2, 2024 Accepted: May 28, 2024 Published online: July 15, 2024 Processing time: 130 Days and 16.5 Hours
Abstract
BACKGROUND
The impact of type 1 diabetes (T1D) on inflammatory bowel disease (IBD) remains unclear.
AIM
To analyze the causal relationship between T1D and IBD using Mendelian ran-domization (MR).
METHODS
Single nucleotide polymorphisms were sourced from FinnGen for T1D, IBD, ulcerative colitis (UC) and Crohn’s disease (CD). Inverse variance-weighted, MR-Egger, and weighted median tests were used to assess exposure-outcome causality. The MR-Egger intercept was used to assess horizontal pleiotropy. Co-chran’s Q and leave-one-out method were used to analyze heterogeneity and sensitivity, respectively.
RESULTS
Our MR analysis indicated that T1D was associated with a reduced risk of IBD [odds ratio (OR): 0.959; 95% confidence interval (CI): 0.938-0.980; P < 0.001] and UC (OR: 0.960; 95%CI: 0.929-0.992; P = 0.015), with no significant association observed in terms of CD risk (OR: 0.966; 95%CI: 0.913-1.022; P = 0.227). The MR-Egger intercept showed no horizontal pleiotropy (P > 0.05). Cochran’s Q and leave-one-out sensitivity analyses showed that the results were not heterogeneous (P > 0.05) and were robust.
CONCLUSION
This MR analysis suggests that T1D serves as a potential protective factor against IBD and UC but is independent of CD.
Core Tip: Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic beta cells. As research progresses, the potential relationship between T1D and inflammatory bowel disease (IBD) has attracted an increasing amount of attention. The study analyzed the causal relationship between T1D and IBD using Mendelian randomization. Our findings indicate that T1D serves as a potential protective factor against IBD and ulcerative colitis but is independent of Crohn’s disease.
