Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2024; 15(6): 1091-1110
Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1091
Clinical characteristics and treatment compounds of obesity-related kidney injury
Tuo-Hua Mao, Han-Qi Huang, Chuan-Hai Zhang
Tuo-Hua Mao, Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Han-Qi Huang, Department of Endocrinology, Hubei No. 3 People’s Hospital of Jianghan University, Wuhan 430033, Hubei Province, China
Chuan-Hai Zhang, Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, United States
Co-corresponding authors: Han-Qi Huang and Chuan-Hai Zhang.
Author contributions: Zhang CH and Huang HQ conceptualized and designed the research; Mao TH, Huang HQ, and Zhang CH wrote the paper; Mao TH, Huang HQ, and Zhang CH searched the literature, and revised and submitted the early version of the manuscript; Zhang CH was responsible for figure plotting. Both Zhang CH and Huang HQ have played important and indispensable roles in the research design and manuscript preparation as the co-corresponding authors. Zhang CH and Huang HQ conceptualized, designed, and supervised the whole process of the project. They searched the literature, and revised and submitted the early version of the manuscript with the focus on the association between obesity and kidney injury. This collaboration between Zhang CH and Huang HQ is crucial for the publication of this manuscript.
Supported by the National Natural Science Foundation of China, No. 82100866 (to Mao TH).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chuan-Hai Zhang, PhD, Assistant Instructor, Department of Physiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, United States. chuanhai.zhang@utsouthwestern.edu
Received: December 6, 2023
Revised: December 22, 2023
Accepted: April 8, 2024
Published online: June 15, 2024
Core Tip

Core Tip: There are a few reviews and summaries on obesity-induced renal injuries. We summarize the pathologic and clinical features of obesity-related nephropathy (ORN) as well as its pathogenesis and potential therapeutics targeting renal inflammation, oxidative stress, insulin resistance, fibrosis, kidney lipid accumulation, and dysregulated autophagy, with an aim to provide new insights into the clinical treatment of ORN.