Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2023; 14(6): 883-891
Published online Jun 15, 2023. doi: 10.4239/wjd.v14.i6.883
Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy
Zhi-Hao Lin, Sheng-Feng Dai, Jian-Nan Zhao, Yue Jiang
Zhi-Hao Lin, Sheng-Feng Dai, Department of Endocrinology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang Province, China
Jian-Nan Zhao, Department of Endocrinology, Yongjia Hospital of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang Province, China
Yue Jiang, Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Lin ZH and Jiang Y concepted the study, supervised the study, contributed to the investigation, the visualization of the study, and originally drafted the manuscript; Dai SF collected the data; Zhao JN contributed to the formal analysis; Dai SF and Zhao JN contributed to the methodology; Jiang Y validated the study; Lin ZH, Dai SF, Zhao JN and Jiang Y reviewed and edited the manuscript.
Institutional review board statement: The study was reviewed and approved by the Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Jiang, MD, Occupational Physician, Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou 325000, Zhejiang Province, China. jyygl9397@126.com
Received: March 14, 2023
Peer-review started: March 14, 2023
First decision: April 7, 2023
Revised: April 16, 2023
Accepted: April 24, 2023
Article in press: April 24, 2023
Published online: June 15, 2023
Processing time: 92 Days and 23.6 Hours
Core Tip

Core Tip: Retinol-binding protein (RBP) can combine with thyroid transporters to form polymer complexes, and activated RBP can free in plasma, pass through glomerular filtration, and be absorbed and decomposed by renal tubules. N-acetyl-β-D-glucosaminidase is a high molecular glycoprotein acidic hydrolase, which is an intracellular lysosomal enzyme mainly present in body fluids, organ tissues and blood cells of the body, and has a high expression especially in the proximal renal tubules, thus being clinically used as an important indicator for the evaluation of renal tubular function.