Lin ZH, Dai SF, Zhao JN, Jiang Y. Application of urinary N-acetyl-β-D-glucosaminidase combined with serum retinol-binding protein in early detection of diabetic nephropathy. World J Diabetes 2023; 14(6): 883-891 [PMID: 37383593 DOI: 10.4239/wjd.v14.i6.883]
Corresponding Author of This Article
Yue Jiang, MD, Occupational Physician, Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou 325000, Zhejiang Province, China. jyygl9397@126.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhi-Hao Lin, Sheng-Feng Dai, Department of Endocrinology, Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang Province, China
Jian-Nan Zhao, Department of Endocrinology, Yongjia Hospital of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang Province, China
Yue Jiang, Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Lin ZH and Jiang Y concepted the study, supervised the study, contributed to the investigation, the visualization of the study, and originally drafted the manuscript; Dai SF collected the data; Zhao JN contributed to the formal analysis; Dai SF and Zhao JN contributed to the methodology; Jiang Y validated the study; Lin ZH, Dai SF, Zhao JN and Jiang Y reviewed and edited the manuscript.
Institutional review board statement: The study was reviewed and approved by the Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang University of Traditional Chinese Medicine Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yue Jiang, MD, Occupational Physician, Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou 325000, Zhejiang Province, China. jyygl9397@126.com
Received: March 14, 2023 Peer-review started: March 14, 2023 First decision: April 7, 2023 Revised: April 16, 2023 Accepted: April 24, 2023 Article in press: April 24, 2023 Published online: June 15, 2023 Processing time: 92 Days and 23.6 Hours
ARTICLE HIGHLIGHTS
Research background
Diabetic nephropathy (DN) is a microangiopathy of type 2 diabetes mellitus (T2DM), which can damage the kidney through various ways and mechanisms due to the nature of the disease, involving the renal interstitium and glomeruli. However, in the early stage of the disease, patients only showed kidney volume increase and glomerular hyperthyroidism, and typical symptoms that are difficult to arouse individual attention were noticed. The symptoms were only noticed when the patients developed edema and proteinuria. At this time, the disease has progressed to an irreversible stage, and the best treatment timing should be taken. Therefore, finding new clinical biochemical factors or examination methods to help early detection of clinical DN patients is particularly important to guide the development of early intervention measures and improve the prognosis of patients.
Research motivation
This study provided new targets for early diagnosis and treatment of DN.
Research objectives
This study aimed to observe the expression of serum retinol-binding protein (RBP) and urinary N-acetyl-β-D-glucosaminidase (NAG) in patients with DN.
Research methods
Total 50 T2DM patients were retrospectively reviewed and included in group A. The baseline data of 50 patients with type 2 DN during the same period were collected and included in group B. The baseline data and serum RBP and urine NAG expression were compared between the two groups to analyze their value in the early prediction of DN.
Research results
The increased expression of urinary NAG and serum RBP may be the risk factors leading to the progression of T2DM to DN.
Research conclusions
The possibility of DN can be considered in patients with urinary NAG and serum RBP overexpression by examining the expression of urinary NAG and serum RBP in patients with T2DM in clinical practice.
Research perspectives
This study showed that urine NAG combined with serum RBP had good application prospects in the early detection of DN. Future studies can further expand the research sample size and improve the diagnostic accuracy of urinary NAG combined with serum RBP.
