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World J Diabetes. Oct 15, 2022; 13(10): 888-899
Published online Oct 15, 2022. doi: 10.4239/wjd.v13.i10.888
Metabonomics fingerprint of volatile organic compounds in serum and urine of pregnant women with gestational diabetes mellitus
Si-Ri-Gu-Leng Sana, Guang-Min Chen, Yang Lv, Lei Guo, En-You Li
Si-Ri-Gu-Leng Sana, Guang-Min Chen, Yang Lv, Lei Guo, En-You Li, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Sana SRGL, Chen GM, Lv Y, Guo L, and Li EY designed the research study; Sana SRGL, Chen GM, Lv Y, and Guo L performed the research, and contributed new reagents and analytic tools; Sana SRGL analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Harbin Medical University.
Clinical trial registration statement: This study is registered with the Chinese Clinical Trial Registry (No. ChiCTR2000038703).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at lienyou_1111@163.com.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: En-You Li, PhD, Doctor, Professor, Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. lienyou_1111@163.com
Received: June 18, 2022
Peer-review started: June 18, 2022
First decision: July 14, 2022
Revised: July 23, 2022
Accepted: September 12, 2022
Article in press: September 12, 2022
Published online: October 15, 2022
Processing time: 117 Days and 18.8 Hours
Core Tip

Core Tip: Gas chromatography-mass spectrometry was used in a metabonomics analysis to determine the changes in volatile metabolites in pregnant women with gestational diabetes mellitus (GDM) and to explore the mechanism of cognitive function decline in these women. 2-propanol was identified as a potential volatile marker to evaluate cognitive impairment in pregnant women with GDM.