Published online Jun 10, 2015. doi: 10.4239/wjd.v6.i5.734
Peer-review started: August 28, 2014
First decision: December 17, 2014
Revised: January 29, 2015
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: June 10, 2015
Processing time: 295 Days and 0.3 Hours
In the epidemiologic context of maternal obesity and type 2 diabetes (T2D), the incidence of gestational diabetes has significantly increased in the last decades. Infants of diabetic mothers are prone to various neonatal adverse outcomes, including metabolic and hematologic disorders, respiratory distress, cardiac disorders and neurologic impairment due to perinatal asphyxia and birth traumas, among others. Macrosomia is the most constant consequence of diabetes and its severity is mainly influenced by maternal blood glucose level. Neonatal hypoglycemia is the main metabolic disorder that should be prevented as soon as possible after birth. The severity of macrosomia and the maternal health condition have a strong impact on the frequency and the severity of adverse neonatal outcomes. Pregestational T2D and maternal obesity significantly increase the risk of perinatal death and birth defects. The high incidence of maternal hyperglycemia in developing countries, associated with the scarcity of maternal and neonatal care, seriously increase the burden of neonatal complications in these countries.
Core tip: Increased mortality and morbidity are historically attributed to neonates of diabetic mothers. A discerning analysis of the literature shows that these adverse outcomes are uncommon among infants born from “pure” gestational diabetes mellitus (GDM) mothers, well managed during pregnancy. Macrosomia is the predominant adverse outcome and the main factor linked to neonatal complications. Poor maternal glycemic control, especially in the context of maternal type 2 diabetes and obesity increases the risk of all adverse neonatal outcomes, most strikingly the risk of perinatal mortality and birth defects. Developing strategies for screening and managing women with GDM must be encouraged notably in middle and low income countries and, also to limit the adverse effects on global health population in the future.