Potential mechanism of Camellia luteoflora against colon adenocarcinoma: An integration of network pharmacology and molecular docking

Table 1 The details of Camellia luteoflora ingredients

No.	Ingredient	Molecular formula	Molecular weight (g/mol)
1	Phytol	C20H40O	296.539
2	β-sitosterol	C29H50O	414.707
3	Daucosterol	C35H60O6	576.847
4	Isoquercitrin	C21H20O12	464.376
5	Anethole	C10H12O	148.202
6	1, 2-Di-O-linolenoylglycerol 3-O-β-D-galactopyranoside	C45H74O10	774.528
7	chlorogenic acid	C16H18O9	354.309
8	Cinchonain Ib	C24H20O9	452.410
9	Cinchonain Ia	C24H20O9	452.410
10	Methyl chlorogenate	C17H20O9	368.340
11	Vitrxin-2-O-rhamnoside	C27H30O14	578.519
12	Isovitexin-2-O-rhamnoside	C27H30O14	578.520
13	Roseoside	C19H30O8	386.437

Table 2 Information of top 10 hub genes intersection sorted by degree and Matthews correlation coefficient value

No.	Gene ID	Degree	MCC
1	TP53	23	173
2	STAT3	14	152
3	ESR1	12	152
4	MAPK8	11	138
5	AKR1C3	11	164
6	RELA	9	131
7	CYP19A1	9	134
8	CYP1A1	9	32
9	JUN	8	138
10	CYP17A1	7	132

MCC: Matthews correlation coefficient.

Table 3 Binding affinity of active ingredients to the hub targets

Ingredient	Target
	ESR1	STAT3	TP53
1-2-Di-O-linolenoylglycerol-3-O-β-D-galactopyranoside	-6.3	-5.5	-5.6
Anethole	-5.6	-4.4	-5.2
β-sitosterol	-6.9	-5.9	-6.4
Chlorogenic acid	-7.8	-6.7	-7.1
Daucosterol	-6.7	-7.2	-6.7
Isoquercitrin	-7.7	-6.8	-6.7
Isovitexin-2-O-rhamnoside	-5.4	-7	-8.2
Phytol	-7	-4.3	-5.3
Roseoside	-7.4	-6.2	-6.9
Vitrxin-2-O-rhamnoside	-1.3	-6.4	-7.7