How is single-cell RNA sequencing contributing to the advancement of cancer therapeutics?

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Apr 15, 2025 (publication date) through Mar 25, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 103480
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.103480

Table 1 Gene profiling with single-cell RNA sequencing targeting gastric cancer in clinical settings[1-5]

Order	Clinical application targeting GC	Target
1	Metastatic characterization	Lipocalin-2, ERBB2, CLDN11, CDK12, FOS, and JUN ↑
2	Finding therapeutic targets	Treg and AKCR1 ↑; DCD1, CTLA4, HAVCR2, LAG-3, and TIGIT ↓; CDH1, RHOA, ERBB2, FGFR2, AXIN1, and PTCH1 mutation
3	Finding prognostic markers	17q, BTF3, CKB, VPS28, TM4SF1, EIF2E, GPX4, and TPM2 ↑

↑ indicates an increased expression; ↓ indicates a decreased expression. GC: Gastric cancer.

Citation: Jeong KY. How is single-cell RNA sequencing contributing to the advancement of cancer therapeutics? World J Gastrointest Oncol 2025; 17(4): 103480
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/103480.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.103480