Jeong KY. How is single-cell RNA sequencing contributing to the advancement of cancer therapeutics? World J Gastrointest Oncol 2025; 17(4): 103480 [DOI: 10.4251/wjgo.v17.i4.103480]
Corresponding Author of This Article
Keun-Yeong Jeong, PhD, Assistant Professor, Head Office, Research Center, PearlsInMires, 150, Yeongdeungpo-ro, Yeongdeungpo-gu, Seoul 07292, South Korea. alvirus@naver.com
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Apr 15, 2025; 17(4): 103480 Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.103480
How is single-cell RNA sequencing contributing to the advancement of cancer therapeutics?
Keun-Yeong Jeong
Keun-Yeong Jeong, Head Office, Research Center, PearlsInMires, Seoul 07292, South Korea
Author contributions: Jeong KY wrote the original draft; Jeong KY contributed to conceptualization, writing, reviewing and editing; Jeong KY participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: This author reports no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Keun-Yeong Jeong, PhD, Assistant Professor, Head Office, Research Center, PearlsInMires, 150, Yeongdeungpo-ro, Yeongdeungpo-gu, Seoul 07292, South Korea. alvirus@naver.com
Received: November 21, 2024 Revised: January 20, 2025 Accepted: January 23, 2025 Published online: April 15, 2025 Processing time: 125 Days and 11 Hours
Abstract
The study of Tang et al investigated the distribution and dynamic changes of cell populations in the tumor microenvironment of gastric cancer (GC) patients using single-cell RNA sequencing (scRNA-seq). This comprehensive analysis highlights key interactions within the tumor microenvironment across different GC stages. Discussing applications of scRNA-seq data in clinical settings could pave the way for developing promising and personalized therapeutic strategies for GC patients. Therefore, further exploration of selecting anticancer drug candidates through gene screening derived from scRNA-seq will provide deeper insights into GC care.
Core Tip: Tang et al explored the distribution and dynamic changes of cell populations within tumor and adjacent tissues of gastric cancer patients using single-cell RNA sequencing (scRNA-seq). In addition to this study, deeper insight into the potential of scRNA-seq will be possible by incorporating information about selecting anticancer drug candidates with gene screening identified by scRNA-seq and their clinical applications.
