Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma

Table 1 Sociodemographic data, lifestyle habits, and presence of diabetes in pancreatic ductal adenocarcinoma patients and controls

Parameter	PDAC, n = 24	CTRL, n = 11	P value
Age	64.75 ± 10.17	58.00 ± 13.94	0.115
Sex as %	54.2 (F), 45.3 (M)	54.5 (F), 45.5 (M)	0.983
Smokers as %	25	33.31	0.632
Coffee consumers as %	63.22	55.51	0.700
Alcohol consumers as %	4.1	01	0.557
Diabetes as %	20.8	01	0.160
Survival in months	4.81 ± 3.253

¹Available for 9 control group patients.

²Available for 19 pancreatic ductal adenocarcinoma patients.

³Available for 16 pancreatic ductal adenocarcinoma patients.

CTRL: Control group; PDAC: Pancreatic ductal adenocarcinoma.

Table 2 Gene expression results

Gene	Our study (24 PDAC vs 11 NT)				OncoDB (200 PDAC vs 178 normal)
	PDAC (2−ΔCT ± SEM)	NT (2−ΔCT ± SEM)	FC	P value1	FC	P value2
CD36	0.527 ± 0.004	0.499 ± 0.009	1.06	0.001	2.893	< 0.001
SLC27A1	0.462 ± 0.003	0.462 ± 0.002	1.00	ns	2.836	< 0.001
FASN	1.325 ± 0.233	0.986 ± 0.222	1.34	ns	1.86	< 0.001
SLC27A2	0.763 ± 0.252	0.135 ± 0.036	5.66	0.033	3.689	< 0.001
SLC27A3	2.384 ± 0.548	0.888 ± 0.168	2.68	0.04	2.948	< 0.001
SLC27A4	0.996 ± 0.367	0.318 ± 0.059	3.13	0.033	2.366	< 0.001
SLC27A5	0.087 ± 0.026	0.045 ± 0.010	1.94	ns	2.385	< 0.001
ACSL1	14.063 ± 2.103	3.424 ± 0.725	4.10	< 0.001	19.043	ns
ACSL3	6.925 ± 1.397	2.593 ± 0.651	2.67	0.012	7.242	< 0.001

¹Mann–Whitney test.

²t-test Student mean.

FC: Fold change; NT: Non-tumoral; PDAC: Pancreatic ductal adenocarcinoma; SEM: Standard error of the mean.