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World J Gastrointest Oncol. Jan 15, 2025; 17(1): 98409
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98409
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98409
Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma
Radu Cristian Poenaru, Elena Milanesi, Andrei Marian Niculae, Anastasia-Maria Dobre, Catalina Vladut, Mihai Ciocîrlan, Daniel Vasile Balaban, Vlad Herlea, Maria Dobre, Mihail Eugen Hinescu, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania
Elena Milanesi, Department of Radiobiology, Victor Babes National Institute of Pathology, Bucharest 050096, Romania
Andrei Marian Niculae, Maria Dobre, Mihail Eugen Hinescu, Department of Pathology, Victor Babes National Institute of Pathology, Bucharest 050096, Romania
Catalina Vladut, Mihai Ciocîrlan, Department of Gastroenterology, Prof. Dr. Agrippa Ionescu Clinical Emergency Hospital, Bucharest 011356, Romania
Vlad Herlea, Department of Pathology, Fundeni Clinical Institute, Bucharest 022258, Romania
Co-first authors: Radu Cristian Poenaru and Elena Milanesi.
Co-corresponding authors: Andrei Marian Niculae and Maria Dobre.
Author contributions: Poenaru RC and Milanesi E contributed equally to this work as co-first authors; Niculae AM and Dobre M contributed equally to this work as co-corresponding authors; Poenaru RC, Milanesi E, Niculae AM, Dobre M, and Dobre AM contributed to methodology, formal analysis, data extraction, writing, reviewing, and editing; Vladut C, Ciocîrlan M, Balaban VD, Herlea V were involved in acquisition and data interpretation; Hinescu ME was involved in supervision; All authors contributed to the interpretation of the study and approved the final version to be published.
Supported by Romanian Ministry of Research, Innovation and Digitization, No. PN23.16.02.04 and No. 31PFE/30.12.2021.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Clinical Emergency Hospital Bucharest (registration number 1960, 28 February 2019) and the Ethics Committee of the “Victor Babes” National Institute of Pathology (approval number 78, 3 December 2019).
Informed consent statement: All the patients signed the written informed consent.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Data sharing statement: The dataset used during the current study is available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maria Dobre, MSc, PhD, Research Scientist, Department of Pathology, Victor Babes National Institute of Pathology, Splaiul Independentei 99-101, Bucharest 050096, Romania. maria_dobre70@yahoo.com
Received: June 25, 2024
Revised: September 17, 2024
Accepted: October 22, 2024
Published online: January 15, 2025
Processing time: 169 Days and 18.1 Hours
Revised: September 17, 2024
Accepted: October 22, 2024
Published online: January 15, 2025
Processing time: 169 Days and 18.1 Hours
Core Tip
Core Tip: In this original article, we show preliminary results of a case-control study in which we analyzed the expression level of nine relevant genes involved in the long-chain fatty acid (FA) import in pancreatic ductal adenocarcinoma (PDAC). We found that three FA transporters (SLC27A2, SLC27A3, and SLC27A4) and two long-chain acyl-CoA synthetases genes