Meta-Analysis
Copyright ©The Author(s) 2024.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2816-2825
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2816
Table 1 Basic characteristics of included studies and Newcastle-Ottawa Scale scores (mean ± SD)
Ref.
Time
Research type
Cases
Gender (male/female)
Age (yr)
Stage
Follow-up time (months)
NOS score
Ueno et al[5]2002Cohort study627393/23460.3 ± 12Ⅰ-Ⅲ153 (80-267)6
Ueno et al[6]2004Cohort study862NANAⅠ-Ⅲ1406
Wu et al[7]2014Cohort study412NA61.4 ± 1261 (11-188)7
Ueno et al[8]2015Cohort study880512/36862.9 ± 13Ⅱ-Ⅲ688
Ueno et al[8]2015Cohort study474268/20666.3 ± 13Ⅱ-Ⅲ686
Ueno et al[9]2017Cohort study821484/33766.2 ± 12Ⅱ-Ⅲ59 (1-86)7
Wu et al[10]2018Cohort study466264/20259.9 ± 1359 (45-144)7
Wu et al[10]2018Cohort study432247/18565.1 ± 1258 (1-87)8
Shin et al[11]2019Cohort study15188/6363.2 ± 11Ⅰ-Ⅳ566
Konishi et al[12]2018Cohort study851407/44466 ± 14Ⅰ-Ⅲ586
Nearchou et al[13]2019Cohort study283184/9962.3 ± 11NA6
Nearchou et al[13]2019Cohort study16387/7663 ± 12NA7
Ueno et al[14]2019Cohort study679400/27964.0 ± 12918
Ueno et al[14]2019Cohort study446267/17967.0 ± 12588
González et al[15]2020Cohort study342179/16365.2 ± 12.6Ⅰ-ⅢNA8
Hacking et al[16]2020Cohort study234111/11864 ± 13I-ⅢNA6
Ao et al[17]2020Cohort study363209/15466.6 ± 1261 (1-136)8
Gonzalez et al[18]2021Cohort study372189/18365.7 ± 12.9Ⅰ-Ⅲ62 (1-170)6
Ueno et al[19]2021Cohort study991601/39065.5 ± 12.269.7 (2.1-105.6)7
Table 2 Meta-regression analysis of recurrence survival and overall survival
Interstitial maturity
Heterogeneous factor
Relapse free survival
Overall survival rate
Coefficient
P value
Coefficient
P value
ImmaturityAge0.0980.80.060.93
Region (Europe and America/Asia)0.0840.810.630.18
Gender (male/female)0.050.930.460.21
Stage (Ⅰ-Ⅱ/Ⅲ-Ⅳ)-0.730.16-0.50.39
Tumor site (node/rectum)0.680.140.460.54
Degree of differentiation (high/medium/low)-0.020.95-0.740.49