Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2816-2825
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2816
Correlation analysis of interstitial maturity and prognosis of colorectal cancer: Meta-analysis
Zhen-Jun Liu, Xu-Wen Zhang, Qi-Qi Liu, Shao-Zhao Wang
Zhen-Jun Liu, Department of Gastrointestinal Surgery, Feicheng People's Hospital, Feicheng 271600, Shandong Province, China
Xu-Wen Zhang, Department of Hepatobiliary Surgery, Feicheng People's Hospital, Feicheng 271600, Shandong Province, China
Qi-Qi Liu, Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Shao-Zhao Wang, Department of Anorectal Word, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, Shandong Province, China
Author contributions: Liu ZJ wrote the manuscript; Zhang XW and Liu QQ collected the data; Wang SZ guided the study. All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Zhao Wang, MM, Doctor, Department of Anorectal Word, Central Hospital Affiliated Shandong First Medical University, No. 105 Jiefang Road, Jinan 250013, Shandong Province, China. wangsztcm@163.com
Received: February 21, 2024
Revised: April 13, 2024
Accepted: April 23, 2024
Published online: June 15, 2024
Processing time: 114 Days and 21.4 Hours
Abstract
BACKGROUND

To investigate the relationship between interstitial maturity and prognosis of colorectal cancer.

AIM

To examine the correlation between interstitial maturity and the prognosis of colorectal cancer.

METHODS

The paper database PubMed, EMBASE, Cochranelibrary, Springerlink, CNKI, and Wanfang database were searched until December 2023. "tumor stroma maturity" "desmoplastic stroma reaction" "desmoplastic reaction" "stroma reaction" "degree of stroma reaction "" stroma classification" "stroma density" "colorectal cancer" "colon cancer" "rectal cancer" "prognosis" were searched for the search terms. Two system assessors independently screened the literature quality according to the inclusion exclusion criteria, Quality evaluation and data extraction were performed for the included literatures, and meta-analysis was performed for randomized control trials included at using Review Manager 5.2 software.

RESULTS

Finally, data of 9849 patients with colorectal cancer from 19 cosets in 15 literatures were included, including 4339 patients with mature type (control group), 3048 patients with intermediate type (intermediate group) and 2456 patients with immature type (immature group). The results of meta-analysis showed: Relapse-free survival [hazard ratio (HR) = 2.66, 95% confidence interval (CI): 2.30-3.08; P < 0.00001], disease-free survival (HR = 3.68, 95%CI: 2.33-5.81; P < 0.00001) and overall survival (HR = 1.70, 95%CI: 1.53-1.87; P < 0.00001) were significantly lower than those in mature group (control group); relapse-free survival (HR = 1.36, 95%CI: 1.17-1.59; P < 0.0001) and disease-free survival rate (HR = 1.85, 95%CI: 1.53-2.24; P < 0.0001) was significantly lower than the mature group (control group).

CONCLUSION

There is the correlation between tumor interstitial maturity and survival prognosis of colorectal cancer, and different degrees of tumor interstitial maturity have a certain impact on the quality of life of colorectal cancer patients.

Keywords: Colorectal tumor; Survival prognosis; Tumor interstitial maturity; Systematic review; Meta-analysis

Core Tip: Our study explored the correlation between interstitial maturity and the prognosis of patients with colorectal cancer through meta-analysis. We will collect and analyze data from the literature on interstitial maturity assessment and prognostic indicators in colorectal cancer patients to verify its relevance and evaluate its application prospects in clinical practice. This study will provide a new perspective for understanding the development mechanisms of colorectal cancer and provide a scientific basis for the formulation of clinical treatment strategies.