Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer

Table 1 Comparison of three types of cell death

Cellular change	Apoptosis	Necrosis	Ferroptosis
Origin	Physiological or pathological signal stimulation	Pathological changes or severe injury	Accumulation of iron-dependent lipid peroxides
Cell morphology	Cell shrinkage	Increased cell volume	Cell shrinkage
Cell membrane morphology	Integrity	Loss of membrane integrity	Breakage and bubble
Chromatin morphology	Nuclear chromatin condensation	No agglutination but flocculation	No agglutination
Organelle morphology	No significant change	Swelling and breakage	Increased mitochondrial membrane density
Apoptotic body	Existence	Inexistence	Inexistence
Change in DNA	Regular degradation and DNA ladder	lrregular degradation and DNA smear	No significant change
Inflammatory response	Existence	Inexistence	Inexistence
Molecular mechanism	Dependence of Caspase	Dependence of RIPK3	Dependence of ROS and Fe

ROS: Reactive oxygen species; RIPK3: Receptor interacting protein kinase 3.