Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2335-2349
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2335
Research progress of ferroptosis regulating lipid peroxidation and metabolism in occurrence and development of primary liver cancer
Yu-Jie Shu, Bo Lao, Ying-Yang Qiu
Yu-Jie Shu, Bo Lao, Department of Gastroenterology, Yinzhou District Second Hospital, Ningbo 315199, Zhejiang Province, China
Ying-Yang Qiu, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore
Author contributions: Shu YJ wrote the manuscript; Lao B and Qiu YY collected the data. All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Jie Shu, MD, Doctor, Department of Gastroenterology, Yinzhou District Second Hospital, No. 1 Qianhe Road, Yinzhou Central District, Ningbo 315199, Zhejiang Province, China. 13738837696@163.com
Received: December 12, 2023
Revised: March 6, 2024
Accepted: April 11, 2024
Published online: June 15, 2024
Processing time: 185 Days and 16 Hours
Core Tip

Core Tip: As a highly aggressive tumor, the pathophysiological mechanism of primary liver cancer has attracted much attention. In recent years, factors such as ferroptosis regulation, lipid peroxidation and metabolic abnormalities have emerged in the study of liver cancer, providing a new perspective for understanding the development of liver cancer. Ferroptosis regulation, lipid peroxidation and metabolic abnormalities play important roles in the occurrence and development of liver cancer. The regulation of ferroptosis is involved in apoptosis and necrosis, affecting cell survival and death. Lipid peroxidation promotes oxidative damage and promotes the invasion of liver cancer cells.