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©The Author(s) 2024.
World J Gastrointest Oncol. May 15, 2024; 16(5): 1737-1744
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.1737
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.1737
Table 1 General survey of case and control groups
Variable | Observation group (n = 60) | Control group (n = 60) | P value |
Age | 60.15 ± 4.25 | 61.38 ± 5.44 | 0.191 |
Sex | 42 | 41 | 0.874 |
Male | |||
Female | 38 | 39 | |
Education | 52 | 55 | 0.718 |
Junior high school and below | |||
High school | |||
College and above | 17 | 13 | |
Economic | 11 | 12 | |
≤ 2000 | 2 | 6 | 0.069 |
2001-2999 | 35 | 44 | |
≥ 3000 | 43 | 30 | |
Inheritance | |||
Yes | 32 | 15 | 0.003 |
No | 48 | 65 | |
Married | |||
Yes | 75 | 71 | 0.263 |
No | 5 | 9 |
Table 2 Comparison of the diagnostic results of different indicators against the results of pathologic tissues
Groups | CA724 | CA19-9 | CA242 | CEA | Combined detection | Total | |||||
Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | Negative | ||
Positive | 61 | 19 | 61 | 19 | 69 | 11 | 61 | 19 | 79 | 1 | 80 |
Negative | 14 | 66 | 17 | 63 | 14 | 66 | 18 | 62 | 2 | 78 | 80 |
Total | 75 | 85 | 78 | 82 | 83 | 77 | 79 | 81 | 81 | 79 | 160 |
Table 3 Difference in findings (%)
Groups | Sensitivity | Specificity | Accuracy | Positive predictive value | Negative predictive value |
CA724 | 76.25 | 82.50 | 79.37 | 81.33 | 77.65 |
CA19-9 | 76.25 | 78.75 | 77.50 | 78.21 | 76.83 |
CA242 | 86.25 | 82.50 | 84.38 | 83.13 | 85.71 |
CEA | 86.25 | 77.50 | 76.88 | 77.22 | 76.54 |
Combined detection | 98.75 | 97.50 | 98.13 | 97.53 | 98.73 |
F | 16.38 | 18.24 | 16.37 | 19.63 | 17.04 |
P value | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Table 4 Differences in serum tumor marker levels between patients with gastric cancer and patients with benign gastric disease
Groups | CA724 | CA19-9 | CA242 | CEA |
Observation group | 17.45 ± 1.25 | 16.83 ± 1.92 | 30.15 ± 4.45 | 27.92 ± 5.26 |
Gontrol group | 1.63 ± 0.37 | 1.45 ± 0.25 | 3.82 ± 0.49 | 4.75 ± 0.44 |
t | 17.28 | 15.66 | 11.63 | 19.02 |
P value | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
- Citation: Zhou CM, Zhao SH. Evaluation of the value of combined detection of tumor markers CA724, carcinoembryonic antigen, CA242, and CA19-9 in gastric cancer. World J Gastrointest Oncol 2024; 16(5): 1737-1744
- URL: https://www.wjgnet.com/1948-5204/full/v16/i5/1737.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i5.1737