Evaluation of the value of combined detection of tumor markers CA724, carcinoembryonic antigen, CA242, and CA19-9 in gastric cancer

Table 1 General survey of case and control groups

Variable	Observation group (n = 60)	Control group (n = 60)	P value
Age	60.15 ± 4.25	61.38 ± 5.44	0.191
Sex	42	41	0.874
Male
Female	38	39
Education	52	55	0.718
Junior high school and below
High school
College and above	17	13
Economic	11	12
≤ 2000	2	6	0.069
2001-2999	35	44
≥ 3000	43	30
Inheritance
Yes	32	15	0.003
No	48	65
Married
Yes	75	71	0.263
No	5	9

Table 2 Comparison of the diagnostic results of different indicators against the results of pathologic tissues

Groups	CA724		CA19-9		CA242		CEA		Combined detection		Total
	Positive	Negative	Positive	Negative	Positive	Negative	Positive	Negative	Positive	Negative
Positive	61	19	61	19	69	11	61	19	79	1	80
Negative	14	66	17	63	14	66	18	62	2	78	80
Total	75	85	78	82	83	77	79	81	81	79	160

CEA: Carcinoembryonic antigen.

Table 3 Difference in findings (%)

Groups	Sensitivity	Specificity	Accuracy	Positive predictive value	Negative predictive value
CA724	76.25	82.50	79.37	81.33	77.65
CA19-9	76.25	78.75	77.50	78.21	76.83
CA242	86.25	82.50	84.38	83.13	85.71
CEA	86.25	77.50	76.88	77.22	76.54
Combined detection	98.75	97.50	98.13	97.53	98.73
F	16.38	18.24	16.37	19.63	17.04
P value	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

CEA: Carcinoembryonic antigen.

Table 4 Differences in serum tumor marker levels between patients with gastric cancer and patients with benign gastric disease

Groups	CA724	CA19-9	CA242	CEA
Observation group	17.45 ± 1.25	16.83 ± 1.92	30.15 ± 4.45	27.92 ± 5.26
Gontrol group	1.63 ± 0.37	1.45 ± 0.25	3.82 ± 0.49	4.75 ± 0.44
t	17.28	15.66	11.63	19.02
P value	< 0.001	< 0.001	< 0.001	< 0.001

CEA: Carcinoembryonic antigen.