Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2024; 16(5): 1737-1744
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.1737
Evaluation of the value of combined detection of tumor markers CA724, carcinoembryonic antigen, CA242, and CA19-9 in gastric cancer
Chong-Mei Zhou, Shao-Hua Zhao
Chong-Mei Zhou, Shao-Hua Zhao, Department of Clinical Laboratory, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China
Author contributions: Zhou CM designed the research study; Zhao SH performed the research; Zhou CM and Zhao SH contributed new reagents and analytical tools; Zhou CM analyzed the data and wrote the manuscript; all authors have read and approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Science and Research Office of Henan Provincial People’s Hospital (Henan).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chong-Mei Zhou, Doctor, Master's Student, Department of Clinical Laboratory, Henan Provincial People’s Hospital, No. 38 Nongke Road, Jinshui District, Zhengzhou 450003, Henan Province, China. vlm010o@163.com
Received: January 12, 2024
Peer-review started: January 12, 2024
First decision: January 30, 2024
Revised: February 8, 2024
Accepted: March 20, 2024
Article in press: March 20, 2024
Published online: May 15, 2024
Processing time: 118 Days and 10.2 Hours
ARTICLE HIGHLIGHTS
Research background

In recent years, the incidence of gastric cancer has been increasing year by year due to changes in people's lifestyle and dietary structure. The early symptoms of gastric cancer are relatively occult, and some patients may experience abdominal pain, nausea, and other symptoms that are often misdiagnosed as simple gastritis or other diseases, resulting in delayed diagnosis and treatment. Therefore, it is crucial to prioritize the diagnosis of gastric cancer.

Research motivation

The aim of this study was to explore the values of combined detection of the tumor markers for diagnosing gastric cancer.

Research objectives

Eighty patients with suspected gastric cancer admitted between January 2023 and January 2023 were surveyed using a questionnaire to obtain basic information, and venous blood was collected for testing.

Research methods

Between January 2020 and January 2023, 80 patients diagnosed with gastric cancer were selected from our hospital were selected as the observation group. The sex and age of patients in the observation group were matched with those in the control group by 1:1, including 80 patients with benign gastric diseases treated at our hospital during the same period. Venous blood of patients with gastric cancer was collected, and serum was separated and stored at 20 °C for testing. Samples were tested using a MAGLUMIX8 immunoanalyzer (New Industries). The carbohydrate antigens (CA) 724, CA199, CA242, and carcinoembryonic antigen (CEA) levels were determined using immunoradiometric and enzyme-linked immunosorbent assays.

Research results

In this study, we found that the mean serum levels of CA724, CEA, CA242, and CA19-9 in patients with gastric cancer were notably higher than those in the non-gastric cancer control group. The specificity, sensitivity, negative predictive value, and accuracy of the combined detection of CA724, CEA, CA242, and CA19-9 in the observation group were higher than those of CA724, CEA, CA242, and CA199 individual detection. The combined detection of CA724, CEA, CA242, and CA19-9 has high diagnostic accuracy and can reduce the occurrence of missed or misdiagnosed cases, promoting early diagnosis and treatment.

Research conclusions

Combined testing with CA724, CEA, CA242, and CA19-9 has high diagnostic accuracy, which can reduce the occurrence of missed or misdiagnosed cases and promote early diagnosis and treatment. However, owing to the small sample size of this study, further evidence is needed to support its widespread use.

Research perspectives

In this study, the levels of CA724, CEA, CA242, and CA19-9 in patients with gastric cancer were compared to those in patients without gastric cancer. To analyze the value of the combined detection of CA724, CEA, CA242, and CA19-9 and to provide a theoretical basis for the clinical screening of patients with gastric cancer.