Retrospective Cohort Study
Copyright ©The Author(s) 2024.
World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1204-1212
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1204
Table 1 Clinicopathological features of multiple primary malignant tumors, % (n/N)
Variable
First primary tumor
Second primary tumor
Third primary tumor
No. of patients, n85852
Median age, yr (range)58 (26-89)61 (35-89)
Sex, n
  Male57570
  Female28282
P value> 0.1
Age, n
  ≤ 50 yr26180
  > 50 yr59672
P value> 0.1
Tumor distribution
  Stomach41.46 (34/85)12.94 (11/85)0
  Small bowel1.18 (1/85)3.53 (3/85)0
  Colon32.94 (28/85)43.53 (37/85)50 (1/2)
  Rectum25.88 (22/85)40.00 (34/85)50 (1/2)
P value< 0.05
Pathological type
  Adenocarcinoma100 (85/85)97.65 (83/85)100 (2/2)
  Neuroendocrine carcinoma01.18 (1/85)0
  GIST 01.18 (1/85)0
P value> 0.1
Clinical stage
  Tis11.32 (6/53)8.22 (6/73)
  I13.20 (7/53)12.33 (9/73)50 (1/2)
  II30.19 (16/53)28.76 (21/73)50 (1/2)
  III37.74 (20/53)27.40 (20/73)
  IV7.55 (4/53)23.29 (17/73)
P value> 0.1
Treatment
  Surgery 17.65 (15/85)14.12 (12/85)50 (1/2)
  Surgery + chemotherapy76.47 (65/85)48.23 (41/85)50 (1/2)
  Chemotherapy ± radiotherapy3.53 (3/85)21.18 (18/85)
  Best supportive care2.35 (2/85)16.47 (14/85)
P value< 0.001
Table 2 Cases and ratios of multiple primary malignant tumors in the gastrointestinal tract
Sites
Number of MPMTs
Total number
Incidence (%)
Incidence (%) in gastrointestinal MPMTs
Stomach453618 1.2426.16
Small bowel41263.172.33
Colon6614504.5538.37
  Left colon4123.84
  Right colon2514.53
Rectum5728651.9933.14