Current clinical trials on gastric cancer surgery in China

Table 1 Topics of major clinical research interests in gastric cancer surgery in China

Group	Subgroup	Research interests
CLASS	CLASS-01	LDG for AGC
	CLASS-02	LTG for EGC
	CLASS-03	LDG for AGC after NACT
	CLASS-04	Laparoscopic spleen-preserving No. 10 LN dissections for AGC
	CLASS-07	LTG for AGC
	CLASS-08	TLTG vs LATG
	CLASS-10	Laparoscopic vs open lower mediastinal lymphadenectomy for EGJ cancer
	CLASS-11	IGC in LG for AGC
	CKLASS01	TLDG vs LADG
Laparoscopic gastrectomy	LG	LG for AGC
	LDG	LDG for AGC (especially in the elderly patients)
	LTG	LTG with spleen-preserving No. 10 LN dissections for AGC
Robotic gastrectomy	RTG	RTG for EGC, AGC
	RDG	RDG for AGC
	TRG	TRG for GC
	Chinese RG	Chinese MIS robot system for GC
Reconstruction	DG	Uncut R-Y, Modified delta-shaped gastroduodenostomy, Modified BII + Braun
	PG	Double tract reconstruction, gastric tube reconstruction, Cheng's giraffe reconstruction
	TG	Functional jejunal interposition, R-Y pouch, Intracorporeal or extracorporeal esophagojejunostomy
The extent of surgical resection	Extended surgery	Bursectomy, type of omentectomy, complete mesogastrium excision, D2+ lymphadenectomy, D2 plus para-aortic nodal dissection, 14v LN dissection
	Limited surgery	D1 lymphadenectomy for elderly patients in AGC, role of No. 10 LN dissections, length of the proximal resection margin for Adenocarcinomas of the EGJ
Image-guided MIS		Method of ICG injection
		Carbon nanoparticles
Functional preservation and organ preservation		PPG or LAPPG, PG, partial gastrectomy
		ESD for EGC, ESD plus laparoscopic regional LN dissection for EGC
ERAS		NACT for AGC patients in ERAS programs
		ERAS in LDG
Reduced port surgery		1-3 ports LG
		Single-incision plus one-port LG
Others		Laparoscopic staging
		3D LTG plus spleen-preserving No. 10 LN dissections for AGC
		4K laparoscopic surgery
		LTG for remnant GC
		Closure of the mesenteric defects
		Intraoperative leak testing in gastrectomy
		Ultrasonic scalpel vs monopolar electrocautery for DG
		Extensive intraoperative peritoneal lavage

AGC: Advanced gastric cancer; CLASS: Chinese laparoscopic gastrointestinal surgery study; DG: Distal gastrectomy; EGC: Early gastric cancer; EGJ: Esophagogastric junction; ERAS: Enhanced recovery after surgery; ESD: Endoscopic submucosal dissection; GC: Gastric cancer; IGC: Indocyanine green; LADG: Laparoscopic-assisted distal gastrectomy; LAPPG: Laparoscopic-assisted preserving distal gastrectomy; LDG: Laparoscopic distal gastrectomy; LG: Laparoscopic gastrectomy; LN: Lymph node; LTG: Laparoscopic total gastrectomy; MIS: Minimally invasive surgery; NACT: Neoadjuvant chemotherapy; PG: Proximal gastrectomy; PPG: Preserving distal gastrectomy; RDG: Robotic distal gastrectomy; RG: Robotic gastrectomy; RTG: Robotic total gastrectomy; TG: Total gastrectomy; TLDG: Totally laparoscopic distal gastrectomy; TLTG: Totally laparoscopic total gastrectomy; TRG: Totally robotic gastrectomy.