Minireviews
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4369-4382
Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4369
Current clinical trials on gastric cancer surgery in China
Shun Zhang, Ren-Hao Hu, Xi-Mao Cui, Chun Song, Xiao-Hua Jiang
Shun Zhang, Ren-Hao Hu, Xi-Mao Cui, Chun Song, Xiao-Hua Jiang, Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China
Co-corresponding authors: Shun Zhang and Xiao-Hua Jiang.
Author contributions: Zhang S and Cui XM collected data from published studies; Zhang S wrote the manuscript draft; Song C aided in the manuscript writing and finalized the manuscript; Zhang S and Jiang XH discussed the review content and critically reviewed the manuscript draft; All authors have read and agreed to the published version of the manuscript.
Supported by Shanghai Pudong New Area Science and Technology Development Fund Special Project for People's Livelihood Scientific Research, No. PKJ2023-Y38.
Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shun Zhang, MD, PhD, Assistant Professor, Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, No. 1800 Road Yuntai, Pudong New District, Shanghai 200120, China. v2zs@hotmail.com
Received: June 4, 2024
Revised: August 14, 2024
Accepted: August 28, 2024
Published online: November 15, 2024
Processing time: 142 Days and 20.6 Hours
Abstract

Gastric cancer (GC) is the leading diagnosed malignancy worldwide, especially in China. Radical surgery is the cornerstone of GC treatment. We reviewed previous clinical trials and aimed to provide an update on the factors related to the surgical treatment of GC. The number of registered clinical trials in the field of GC surgery is rapidly increasing. With the development and popularization of endoscopic, laparoscopic, and robotic techniques, GC surgery has gradually entered a new era of precise minimally invasive surgery. Postoperative quality of life has become a major issue in addition to surgical oncological safety. Although great progress has been made in clinical research on GC in China, there are still deficiencies. Many studies enrolled large numbers of patients, but the research data were not of high quality. The characteristics of GC in China include a high incidence, large population, and large proportion of patients with advanced GC, which provides sufficient reason for studying this disease. There is still a need for well-designed, large, randomized clinical trials to improve our knowledge of the surgical treatment of GC.

Keywords: Gastric cancer; Clinical trial; Surgery; China; Minimally invasive surgery; Quality of life

Core Tip: Gastric cancer (GC) is the leading common malignancy in China. This review summarizes the study design and the clinical or translational research focus to explore the state-of-the-art and development trends in Chinese GC cancer surgery studies.