Burden landscape of hepatobiliary and pancreatic cancers in Chinese young adults: 30 years’ overview and forecasted trends

Table 1 The incidence numbers and age-standardized incidence rate of primary liver cancer, gallbladder and biliary tract cancer and pancreatic cancer in 1990 and 2019 and their temporal trends from 1990 to 2019

Characteristics	1990		2019		1990-2019
	Numbers	ASIR per 100000	Numbers	ASIR per 100000	EAPC (95%CI)
Liver cancer
Both	68811.36	10.29	44399.27	6.16	-3.51 (-4.44, -2.57)
Male	55050.88	15.94	38449.92	10.40	-3.10 (-4.01, -2.18)
Female	13760.48	4.26	5949.34	1.69	-5.27 (-6.25, -4.28)
Gallbladder and biliary tract cancer
Both	1821.08	0.27	3027.00	0.42	1.88 (1.69, 2.06)
Male	1007.66	0.29	1908.18	0.52	2.76 (2.42, 3.11)
Female	813.42	0.25	1118.83	0.32	0.72 (0.44, 1.00)
Pancreatic cancer
Both	4207.14	0.63	10997.43	1.53	3.26 (3.08, 3.43)
Male	2765.73	0.80	8085.22	2.19	4.06 (3.82, 4.31)
Female	1441.40	0.45	2912.20	0.83	1.59 (1.20, 1.97)

ASIR: Age-standardized incidence rate; EAPC: Estimated average percentage change.

Table 2 The mortality numbers and age-standardized mortality rate of primary liver cancer, gallbladder and biliary tract cancer and pancreatic cancer in 1990 and 2019 and their temporal trends from 1990 to 2019

Characteristics	1990		2019		1990-2019
	Numbers	ASMR per 100000	Numbers	ASMR per 100000	EAPC (95%CI)
Liver cancer
Both	62017.77	9.28	33735.15	4.68	-4.09 (-5.03, -3.15)
Male	49755.43	14.40	29235.06	7.91	-3.72 (-4.63, -2.81)
Female	12262.34	3.80	4500.08	1.28	-5.68 (-6.70, -4.65)
Gallbladder and biliary tract cancer
Both	1477.00	0.22	2154.66	0.30	1.41 (1.22, 1.60)
Male	819.84	0.24	1385.09	0.37	2.36 (2.02, 2.71)
Female	657.16	0.20	769.57	0.22	0.12 (-0.18, 0.42)
Pancreatic cancer
Both	3769.90	0.56	9809.53	1.36	3.26 (3.08, 3.44)
Male	2490.14	0.72	7253.48	1.96	4.06 (3.81, 4.31)
Female	1279.75	0.40	2556.05	0.73	1.56 (1.18, 1.94)

ASMR: Age-standardized mortality rate; EAPC: Estimated average percentage change.

Table 3 The disability-adjusted life years numbers and age-standardized disability-adjusted life years rate of primary liver cancer, gallbladder and biliary tract cancer and pancreatic cancer in 1990 and 2019 and their temporal trends from 1990 to 2019

Characteristics	1990		2019		1990-2019
	Numbers	ASDR per 100 000	Numbers	ASDR per 100 000	EAPC (95%CI)
Liver cancer
Both	3022653.23	452.18	1598256.61	221.76	-4.20 (-5.12, -3.27)
Male	2417358.23	699.80	1384244.50	374.50	-3.82 (-4.71, -2.93)
Female	605295.00	187.38	214012.11	60.95	-5.83 (-6.84, -4.80)
Gallbladder and biliary tract cancer
Both	72354.41	10.82	100846.97	13.99	1.21 (1.03, 1.38)
Male	40283.60	11.66	65189.56	17.64	2.17 (1.83, 2.51)
Female	32070.81	9.93	35657.41	10.16	-0.10 (-0.40, 0.20)
Pancreatic cancer
Both	184481.52	27.60	457701.30	63.51	3.04 (2.88, 3.21)
Male	121551.46	35.19	338968.44	91.71	3.86 (3.63, 4.10)
Female	62930.05	19.48	118732.87	33.82	1.32 (0.94, 1.70)

ASDR: Age-standardized disability-adjusted life years rate; EAPC: Estimated average percentage change.