Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2024; 16(10): 4177-4193
Published online Oct 15, 2024. doi: 10.4251/wjgo.v16.i10.4177
Burden landscape of hepatobiliary and pancreatic cancers in Chinese young adults: 30 years’ overview and forecasted trends
De-Sheng Chen, Ze-Ping Chen, Dong-Zi Zhu, Lv-Xin Guan, Qi Zhu, Yi-Chao Lou, Ze-Ping He, Hao-Nan Chen, Hong-Cheng Sun
De-Sheng Chen, Ze-Ping Chen, Qi Zhu, Yi-Chao Lou, Ze-Ping He, Hong-Cheng Sun, Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Dong-Zi Zhu, Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Lv-Xin Guan, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China
Hao-Nan Chen, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Co-first authors: De-Sheng Chen and Ze-Ping Chen.
Co-corresponding authors: Hao-Nan Chen and Hong-Cheng Sun.
Author contributions: Chen DS, Chen ZP and Zhu DZ curated the data; Guan LX and Zhu Q conducted the formal analysis, with Lou YC and He ZP contributing to the methodology; Chen DS and Chen ZP visualized the results. Chen DS and Zhu DZ wrote the original draft; All authors have reviewed and approved the final manuscript. Chen DS and Chen ZP contributed equally to this study as co-first authors. Both Sun HC and Chen HN have played important and indispensable roles in the project conception, data interpretation and manuscript preparation as the co-corresponding authors. Sun HC conceptualized, designed, and supervised the whole process of the project. Chen HN was responsible for guiding data re-analysis and re-interpretation, figure plotting, preparation and submission of the current version. This collaboration between Sun HC and Chen HN is crucial for the publication of this manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong-Cheng Sun, MD, PhD, Chief Doctor, Chief Physician, Surgeon, Surgical Oncologist, Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China. hongcheng.sun@shgh.cn
Received: June 16, 2024
Revised: August 18, 2024
Accepted: August 28, 2024
Published online: October 15, 2024
Processing time: 101 Days and 15.3 Hours
Core Tip

Core Tip: The landscape of hepatobiliary and pancreatic (HBP) cancers among young adults (aged 15 to 49 years) in China was characterized by an overall increasing trend in addition to a substantial burden. This highlighted the persistently high prevalence of HBP malignancies. In general, adopting healthy lifestyle habits such as practicing tobacco control, maintaining a healthy weight, reducing alcohol consumption, and avoiding drug use could help decrease the risk of developing HBP cancers. These findings offered a comprehensive perspective for guiding healthcare approaches focused on primary prevention for Chinese youth.