Copyright ©The Author(s) 2023.
World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1520-1530
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1520
Table 1 MALAT1 overexpression and clinical characteristics in GC patients
Clinical implications
61 GC/DM, 50 GC/NDM, 36 CPlasma, tissueStaging, MetastasisXia et al[38]
150 GC, 15 peritumoral paraffin-embeddedTissueOS, PFSLi et al[49]
78 GC, 78 NTATTissueStaging, LNMLi et al[52]
60 GC, 60 NTATTissueStaging, LNM, Tumor sizeZhang et al[53]
20 GC, 20 NTATTissueMetastasisChen et al[54]
70 GC, 70 CSerumStagingLu et al[39]
89 GC, 89 NTATTissueLNM, Tumor sizeYan et al[32]
64 GC, 64 NTAT, 64 CTissue, plasmaMetastasisZhu et al[33]
30 GC, 30 NTATTissueVascular invasion, Lymphatic invasionEsfandi et al[30]
37 GC, 37 NTATTissueStagingLi et al[34]
30 GC, 30 NTATTissueOSDai et al[35]
24 GC, 24 NTAT, 24 GC/OXATissueChemoresistanceZhang et al[36]
Table 2 MALAT1 molecular mechanism in GC
Cell line
Molecular interactions
Main discoveries
MKN28, SGC7901, BCG823, GES1EGFL7MALAT1/EGFL7 axis promotes metastasis and cell invasionDeng et al[46]
MKN45, AGS, GES1EZH2/PCDH10MALAT1 recruits EZH2 to inhibit the synthesis of cadherin PCDH10, promoting metastasisQi et al[55]
SGC7901, MKN 45, BGC823, CTC141, CTC105, GES1miR-122/IGF1RmiR-122/IGF1R axis causes dysregulation of MALAT1, increasing cell invasion and migration of cellsXia et al[38]
SGC7901, MKN45, BGC823, AGS, SGC7901NM, SGC7901M, GES1E-cadherin, vimentin, SLUG, SNAIL, TWISTMALAT1 contributes to cell migration, invasion, and proliferation by upregulating EMT markers and downregulating E-cadherinChen et al[54]
MKN28, MKN74, AGSRASSF6, β-cateninDysregulation of MALAT1 improves the expression of β-catenin and other EMT markers, promoting metastasisLee et al[56]
BGC823, SGC7901, HEK293T, GES1UPF1Overexpression of MALAT1 causes hypermethylation of the UPF1 promoter, increasing cell migration, invasion, and proliferationLi et al[57]
BGC823, SGC7901, MKN45, AGS, BGC803, MGC803, GES1VE-cadherin/β-catenin, ERK/MMP, FAK/paxillinMALAT1 promotes angiogenesis by through vasculogenic mimicryLi et al[49]
BGC823, SGC7901, MKN45, MKN28, GES1miR-1297/HMGB2MALAT1/miR-1297 increases HMGB2 protein, promoting cell invasion and proliferation of cellsLi et al[52]
SGC7901, SGC7901/VCR, BGC823miR-23b-3p/ATG12MALAT1/miR-23b-3p, promotes drug resistance via the ATG12 proteinYiRen et al[37]
SGC7901, MKN45, MKN28, GES1miR-202/GLI2MALAT1/miR-202, increases GLI2 expression, inducing tumor progression and cell proliferationZhang et al[53]
BGC823, SGC7901, GES1Vimentin, E-cadherinMALAT1 decreases E-cadherin and increases vimentin expression, promoting EMTYang et al[58]
BGC823, HGC27, SGC7901, GES1miR-183/SIRT1, PI3KCA/AKT/mTORMALAT1/miR-183 increases SIRT1 protein expression, increasing cell viability, and inhibiting cell apoptosisLi et al[59]
MGC803, GES1miR-181a-5p/AKT3MALAT1/miR-181a-5p increases AKT3 protein expression, promoting cell proliferation and inhibiting cell apoptosisLu et al[39]
MKN45, SGC7901, GES1Vimentin, E-cadherin, SOX2MALAT1 increases cell stemness via the SOX2 protein, and promotes metastasisXiao et al[60]
BGC823, HGC27, MKN45, AGS, GES1IL-21R/miR-125aMALAT1/miR-125a increases IL-21R expression, increasing cell invasionYan et al[32]
AGS, SNU1PI3KCA/AKTMALAT1 contributes to cell proliferation, invasion, and migration through the PI3KCA/AKT pathwayZhu et al[33]
MKN45, MKN28, MGC803, MGC803/CDDP, HGC27, NCIN87, AGS, GES1PI3KCA/AKTMALAT1 increases PI3KCA, AKT and STAT3 activity, promoting resistance to cisplatinDai et al[35]
SGC7901, BGC823, GES1miR-22-3p/ErbB3MALAT1/miR22-3p inhibits cell apoptosisLi et al[34]
CTC141, CTC105, MKN45, GES1miR-204/MAP1LC3B/TRPM3MALAT1/miR-204 increases the expression of LC3B and TRPM3, promoting autophagyShao et al[18]
SGC7901, BGC823, SGC7901/OXA, BGC823/OXAmiR22-3p/ZFP91MALAT1 increases resistance to OXAZhang et al[36]
SGC7901, SGC7901/CDDPmiR-30e/ATG5MALAT1 acts as a ceRNA to miR-30e, raising cisplatin resistance and autophagy via the miR-30e/AGT5 axisZhang et al[61]
SGC7901, MGC803, HEK293TCCL21, miR-202-3p/SRSF1, SRSF1/mTORMALAT1 promotes EMT through miR-202-3p/SRSF1/ mTORFu et al[45]