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World J Gastrointest Oncol. Sep 15, 2023; 15(9): 1520-1530
Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1520
Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression
Daniel Mateus de Oliveira Batista, Jéssica Manoelli Costa da Silva, Carolina de Oliveira Gigek, Marília de Arruda Cardoso Smith, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno
Daniel Mateus de Oliveira Batista, Jéssica Manoelli Costa da Silva, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém 66073-000, Pará, Brazil
Carolina de Oliveira Gigek, Departamento de Patologia, Universidade Federal de São Paulo, São Paulo 04023-062, São Paulo, Brazil
Marília de Arruda Cardoso Smith, Disciplina de Genética,Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo 04023-900, São Paulo, Brazil
Author contributions: Batista DMO, da Silva JMC, Calcagno DQ wrote the paper; Batista DMO designed the tables and the figures; Smith MAC, Gigek CO, and de Assumpção PP critically revised this paper; Calcagno DQ designed the article.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Danielle Queiroz Calcagno, PhD, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, R. dos Mundurucus, 4487-Guamá, Belém-PA, Belém 66073-000, Pará, Brazil. danicalcagno@gmail.com
Received: May 2, 2023
Peer-review started: May 2, 2023
First decision: May 9, 2023
Revised: May 30, 2023
Accepted: July 27, 2023
Article in press: July 27, 2023
Published online: September 15, 2023
Processing time: 133 Days and 12.3 Hours
Core Tip

Core Tip: Gastric cancer (GC) is one of the leading causes of cancer-related deaths globally, highlighting the need for novel biomarker for improved evaluation. The long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a crucial role in many cellular processes associated with GC progression, including proliferation, invasion, metastasis, and drug response. The current review summarizes the present knowledge of MALAT1 in GC, elucidating its molecular mechanisms of action and potential as a biomarker for the clinical management of GC.