Role of inositol polyphosphate-4-phosphatase type II in oncogenesis of digestive system tumors

Table 1 Role of inositol polyphosphate-4-phosphatase type II in tumors of the digestive system

Cancer	Role	Molecular pathway	Ref.
Gastric cancer	Carcinostasis	AKT, p-AKT, SGK3, SGK3	[29-34,39]
	Dual function	AKT, p-AKT, SGK3, SGK3, HIF-1A	[40,41]
Colon cancer	Carcinostasis	MiR-1290, p27, cyclin D1	[42-44]
	Carcinogenesis	Ets-1, PTEN, PI3K/AKT, PI3K/SGK3	[18,19,45-48]
	Dual function	Sox2, Nanog	[13]
Pancreatic cancer	Carcinostasis	Methylation inhibitors, PI3K/AKT, Ecad	[16,49,50]
	Carcinogenesis	PI3K/AKT	[51]
Liver cancer	Carcinostasis	MiR-765, AKT, p-AKT, Cyclin D1, p-FOXO3a, p21	[10,53-56]
Esophageal cancer	Carcinogenesis	AKT, pAKT	[20]
Gallbladder cancer	Dual function	AKT, p-AKT, SGK3, p-SGK3	[41,57]

AKT: Protein kinase B; p-AKT: Phosphorylated AKT; SGK3: Serum and glucocorticoid-regulated kinase 3; p-SGK3: Phosphorylated SGK3; HIF-1A: Hypoxia inducible factor-1A; Ets-1: E26 transformation-specific 1; PTEN: Phosphate and tensin homolog deleted on chromosome 1; PI3K: Phosphoinositide 3-kinase; SOX2: Recombinant sex determining region Y box protein 2; Ecad: E-cadherin; p-FOXO3a: Phosphorylated Forkhead box O3.