Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2023; 15(10): 1706-1716
Published online Oct 15, 2023. doi: 10.4251/wjgo.v15.i10.1706
Role of inositol polyphosphate-4-phosphatase type II in oncogenesis of digestive system tumors
Le Han, Shuo Chen, Shi-Yu Du
Le Han, Peking University China-Japan Friendship School of Clinical Medicine, Peking University, Beijing 100029, China
Shuo Chen, Shi-Yu Du, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Han L contributed significantly to conceptualization, data analysis, and manuscript preparation; Du SY and Chen S helped perform data analysis with constructive discussions; all authors read and approved the final version of the manuscript.
Supported by the China-Japan Friendship Hospital Foundation, No. 2019-1-QN-2.
Conflict-of-interest statement: The authors declare that they have no competing interests to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Shuo Chen, MD, Doctor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 East Yinghua Street, Chaoyang District, Beijing 100029, China.
Received: June 13, 2023
Peer-review started: June 13, 2023
First decision: July 31, 2023
Revised: August 22, 2023
Accepted: September 19, 2023
Article in press: September 19, 2023
Published online: October 15, 2023
Core Tip

Core Tip: Inositol polyphosphate-4-phosphatase type II (INPP4B) is a newly discovered PI(3,4,5)P3 phosphatase. This paper reviews studies on the correlations between INPP4B and digestive system tumors and the roles of INPP4B in the development of different tumors to provide a theoretical basis for further research on its molecular mechanism and clinical application. The abnormal expression of INPP4B plays an important role in the development of digestive system tumors. Studies on INPP4B provide new molecular insights for the diagnosis, treatment, and prognosis evaluation of digestive system tumors.