Review
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. May 15, 2022; 14(5): 973-988
Published online May 15, 2022. doi: 10.4251/wjgo.v14.i5.973
Table 1 EFNA1 gene information
Gene name (known as)
Position and length
Exon number
Encoding mRNA and protein
5’UTR
CDS
3’UTR
EFNA1 (ephrin-A1; B61; EFL1; GMAN; ECKLG)1q22; 7024bp5 (1..194, 3464..3759, 5682..5693, 5855..5905,6082..7024) NM_004428.3, 1552bp, NM_182685.2, 1486 bp; NP_004419.2 , 205aa, NP_872626.1, 183 aa1..103103..194, 3464..3759, 5682..5693, 5855..5905,6082..70246192..7024
Table 2 EFNA1 prognostic value in gastrointestinal cancers
Tumor type
Sample type
Expression
Methods
Prognosis value
Notes
Ref.
Gastric cancerTissues IncreasedRT-PCR (-)EFNA1 expression is related to GC stage, depth of invasion, lymph node metastasis and recurrenceNakamura et al[30], 2005
TissuesIncreasedIHCPoor DSS(-)Miyazaki et al[32], 2013
TissuesIncreasedIHC, RT-PCRPoor DSSEFNA1 expression is related to TNM and lymph node metastasisYuan et al[33], 2009
TissuesIncreasedRT-PCR(-)SNP (rs12904G>A) can regulate the expression of EFNA1 and is related to GC susceptibilityLi et al[34], 2014
TissuesIncreased(-)(-)EFNA1 expression increase the susceptibility of GCZhu et al[35], 2015
TissuesIncreased(-)(-)EFNA1 expression may be related to GC susceptibility Lee et al[36], 2015
TissuesIncreasedIHC, RT-PCRPoor DSSGMAN up-regulates the expression of EFNA1 and promotes the transfer of GCZhou et al[37], 2019
Colorectal cancerCells(-)(-)(-)EFNA1 overexpression can inhibit the growth of HT29 cellsPotla et al[42], 2002
TissuesIncreasedIHC, RT-PCR(-)The expression of EFNA1 promotes the development of rectal adenocarcinoma to rectal cancerShi et al[43], 2012
TissuesIncreased(-)(-)EFNA1 may be used as a diagnostic biomarker for the characteristics of CRC. In addition, the rs12904G/A variant is related to the susceptibility to CRCMao et al[44], 2013
Cells(-)(-)(-)Eck and B61 are co-expressed in the same cell, suggesting the existence of an autocrine loopRosenberg et al[46], 1997
TissuesIncreasedRT-PCRPoor DSSDecreased survivalKataoka et al[47], 2004
CellsReduced(-)Poor DSSEFNA1 can be used as a prognostic marker for CRCRobertis et al[48], 2017
TissuesIncreasedRT-PCRPoor DSSEFNA1 is an independent prognostic factor for CRCYamamoto et al[49], 2013
SerumIncreasedIHC, QRT-PCRPoor DSSEFNA1 may be used for the identification of CRCLip et al[50], 2008
Hepatocellular carcinomaTissuesIncreasedRT-PCRPoor DSSThe high expression of EFNA1 protein is related to histological differentiation, portal vein tumor thrombus and lymph node metastasisZhang et al[54], 2007
TissuesIncreasedRT-PCRPoor DSSEFNA1 is an independent prognostic factor of HCCWada et al[55], 2014
TissuesIncreasedIHCPoor DSSEFNA1 is involved in the mechanism of AFP induction in HCCLida et al[57], 2005
Tissues, SerumIncreasedIHC, RT-PCRPoor DSSThe expression of EFNA1 is positively correlated with AFPCui et al[58], 2010
Esophageal cancerTissuesIncreasedIHC, RT-PCRPoor DSSDecreased survivalXu et al[59], 2005
TissuesIncreased(-)Poor DSSDecreased survivalChen et al[60], 2019
CellsIncreasedRT-PCR(-)High expression of EFNA1 decreased the viability of ESCC cellsYang et al[61], 2015