Effect of hepatic artery resection and reconstruction on the prognosis of patients with advanced hilar cholangiocarcinoma

Table 1 Comparison of baseline data between the two groups, n (%)

Normal information	Reconstruction group (n = 40)	Regular group (n = 58)	t/χ2 value	P value
Age (yr)	58.6 ± 7.0	59.0 ± 6.6	-0.2877	0.77422
Body mass index (kg/m2)	22.6 ± 1.9	22.8 ± 2.3	-0.4533	0.65132
Sex			1.319	0.251
Male	28 (70)	34 (58.62)
Female	12 (30)	24 (41.38)
Surgical approach			1.227	0.746
Cholangiocarcinoma resection	11 (27.5)	22 (37.93)
Left liver + Caudate lobe	13 (32.5)	15 (25.86)
Right liver + Caudate lobe	12 (30)	16 (27.59)
Other types	4 (10)	5 (8.62)
Bismuth-Corlette type			1.179	0.758
I type	14 (35)	25 (43.1)
II type	16 (40)	21 (36.21)
III type	8 (20)	8 (13.79)
IV type	2 (5)	4 (6.9)
Regional lymph node metastasis			0.764	0.382
Yes	18 (45)	21 (36.21)
No	22 (55)	37 (63.79)
Adjuvant chemotherapy			1.696	0.193
Yes	35 (87.5)	55 (94.83)
No	5 (12.5)	3 (5.17)

Table 2 Comparison of surgical trauma indexes between the two groups (mean ± SD)

Group	n	Operation time (min)	Surgical bleeding (mL)	Gastrointestinal function recovery time (h)	Hospital stay (d)
Reconstruction group	40	11.36 ± 1.03	906.8 ± 155.3	73.6 ± 13.0	21.61 ± 3.9
Regular group	58	9.71 ± 0.81	720.3 ± 160.1	64.8 ± 11.0	19.3 ± 3.2
t value		8.863	5.737	3.612	3.210
P value		0.000	0.000	0.000	0.002

Table 3 Comparison of the effect of operational resection between the two groups, n (%)

Group	n	R0 excision	Non-R0 resection
Reconstruction group	40	36 (90.00)	4 (10.00)
Regular group	58	42 (72.41)	16 (27.59)
χ2		4.507
P value		0.034

Table 4 Comparison of Karnofsky performance status scores between the two groups of patients before and after operation (mean ± SD, scores)

Group	n	Preoperative	2 wk after surgery	8 wk after surgery
Reconstruction group	40	75.1 ± 4.2	66.9 ± 5.0	76.7 ± 4.8
Regular group	58	73.7 ± 3.5	64.0 ± 5.7	75.4 ± 5.0
χ2		1.793	2.600	1.286
P value		0.076	0.011	0.202

Table 5 Comparison of liver function indexes between two groups of patients (mean ± SD)

Index	Preoperative	1 d after operation	3 d after operation
ALT (U/L)
Reconstruction group	78.9 ± 19.6	451.2 ± 88.1	357.1 ± 93.0
Regular group	83.0 ± 20.1	489.8 ± 94.7	401.2 ± 85.0
t value	-1.003	-2.040	-2.429
P value	0.319	0.044	0.017
AST (U/L)
Reconstruction group	83.5 ± 28.0	438.1 ± 93.0	395.8 ± 81.7
Regular group	80.0 ± 24.6	470.7 ± 87.2	441.5 ± 96.1
t value	0.654	-1.770	-2.456
P value	0.515	0.080	0.016
TBIL (μmol/L)
Reconstruction group	144.3 ± 35.1	122.2 ± 28.0	44.1 ± 13.0
Regular group	138.5 ± 37.3	118.0 ± 26.9	40.0 ± 12.5
t value	0.775	0.747	1.570
P value	0.440	0.457	0.120

ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBIL: total bilirubin.

Table 6 Observation of complication rate

Group	n	Biliary fistula	Liver failure	Incision infection	Urinary tract infection	Lung infection	Complication rate, n (%)
Reconstruction group	40	1	1	2	4	3	11 (27.50)
Regular group	58	3	2	3	5	6	19 (32.76)
χ2							0.308
P value							0.579

Table 7 Two-year survival rate observation, n (%)

Group	n	Survive	Death
Reconstruction group	40	17 (42.50)	23 (57.50)
Regular group	58	23 (39.66)	35 (60.34)
χ2		0.079
P value		0.778