Chen et al[29] | M/60 | Abdominal pain | Emergency surgery followed by CHOP + IVE/MTX + SCT, followed by ASCT | CR; liver recurrence 2.5 years later refractory to GDP regimen. Passed away 2 wk after recurrence |
Ishibashi et al[30] | M/60 | Diarrhea and 10 kg weight loss in 17 mo | CHASE followed by SCT | 3 years |
F/40 | Diarrhea and 6 kg weight loss in 3 mo | THP-COP followed by surgery 10 mo later | 2 mo after surgery |
F/50 | Abdominal distension | CHOP + high-dose MTX + SCT | 9 mo |
M/70 | Nausea | SMILE | 9 mo |
Aiempanakit et al[31] | M/67 | Diarrhea for 4 mo and 15 kg weight loss over 3 mo | Anthracycline-based regimen | 2 mo |
Antoniadu et al[32] | M/76 | Severe dyspnea | N/A | 5 d |
Aoyama et al[33] | M/85 | Fever and diarrhea | CHOP followed by DeVIC | Not stated but deceased subsequently due to progressive disease |
Pan et al[34] | F/67 | Abdominal pain | 1 cycle of CEOP | 3.7 mo |
Liu et al[35] | F/48 | Abdominal pain, distension, vomiting, watery diarrhea, weight loss | Unspecified chemotherapy | 1 mo after chemotherapy initiation |
Ozaka et al[36] | F/68 | Melena and mild anemia | 8 cycles of CHOP | Achieved complete remission and was still alive at the time of publication (68 mo after diagnosis) |
Kasinathan et al[37] | F/70 | Abdominal pain and vomiting for 4 wk | 2 cycles of CHOP, followed by 2 cycles of GDP | Developed gastrointestinal bleeding and succumbed 4 wk after initiation of GDP |
Mago et al[38] | M/59 | SOB for 1 mo, abdominal distension for 2 wk | 1 cycle of CHOEP | Passed away within few days after tumor lysis syndrome |
Nato et al[39] | F/43 | Abdominal distension, 2 mo history of early satiety and nausea | 4 cycles of GDP achieving a PR, CR was achieved after CBT conditioned with total body irradiation, cyclophosphamide, and cytarabine | Cognitive impairment (7 mo post transplantation) was improved after 3 cycles of MPV and whole brain radiotherapy and passed away 6 mo later |
Pan et al[40] | M/63 | Diffuse abdominal pain for 1 mo | Emergency surgery followed by 2 cycles of CHOP | 2 mo |
M/47 | Diarrhea, dyspnea, orthopnea, weight loss for 1 year | 1 dose of L-asparaginase, etoposide, and decadron regimen followed by emergency surgery, adjuvant chemotherapy included etoposide, methylprednisolone, high-dose cytarabine, and cisplatin | 9 mo |
Umino et al[41] | M/41 | Diarrhea and epigastric pain for 1 mo | 3 neoadjuvant cycles of ICE followed by autologous SCT | 13 mo |
Ferran et al[42] | F/45 | Cutaneous lesions followed by abdominal perforation after chemotherapy initiation | 6 neoadjuvant cycles of CHOP and 1 cycle of SMILE followed by surgery. 1 adjuvant cycle L-GEMOX | 8 mo |
Aoki et al[43] | F/77 | Abdominal discomfort, night sweats, and fever for 1 mo | EPOCH for 6 mo | Still alive 1 year after diagnosis |
Soardo et al[44] | M/65 | 2-wk history of weight gain, increased abdominal volume with progressive mild dyspnea, and fever in the last 2 d | Emergency laparotomy | 1 mo postoperatively |
Liu et al[45] | M/61 | Upper abdominal pain and black stool for 2 mo | Partial excision of small intestine and chidamide-based combination regimen | 15 mo |
F/35 | Abdominal distension for 1 mo | Sigmoid colostomy followed by chidamide-based combination therapy | 17 mo |
Samuel et al[46] | M/62 | Hypovolemic shock secondary to severe chronic diarrhea and 100 pounds lost over a year | Chemotherapy | 1 mo |
Ikeda et al[47] | M/61 | 3 episodes of ileal strangulation within 4 mo of gastrectomy | Ileal resection followed by 2 cycles of CHOP and 1 cycle of ICE | 3 mo |
Lenti et al[48] | F/63 | Diarrhea and 10 kg weight loss in 6 mo | Surgery followed by a single course of CHOP | 27 mo |
M/58 | Diarrhea and 5 kg weight loss | Surgery | 4 mo |
Broccoli et al[49] | M/65 | Petechiae at both limbs, acute abdominal pain, diarrhea, and clinical signs of bowel perforation | Emergency resection of 9 cm of small bowel | 6 mo |
Tabata et al[50] | M/72 | Ileum perforation…severe constipation after 21 mo in CR | Emergency resection followed by anthracycline-based regimen chemotherapy (CR for 21 mo), paltrexate therapy was administered during recurrence | In CR after 52 mo |
Fisher et al[51] | F/60 | Abdominal pain, diarrhea, and 30 pounds of weight loss over 3 mo | EOCH chemotherapy (subsequently developing a large lymphoma 6 mo after therapy initiation) | N/A |
Tian et al[8] | M/58 | Abdominal pain, diarrhea, and weight loss over 3 mo | 1 course of CHOP | Died subsequently after the first cycle due to bone marrow suppression |
F/64 | Abdominal pain and diarrhea for 5 years | 5 wk of adjuvant chemotherapy consisting of romidepsin with Revlimid followed by laparotomy involving small bowel bypass | 3 mo |
Kubota et al[52] | M/41 | Diarrhea for 1 mo and intermittent abdominal pain | Resection followed by CHOP and 3 cycles of ICE resulted in CR | Repeated intrathecal chemotherapy and high-dose chemotherapy followed by ASCT achieved CR |
Gentille et al[53] | F/70 | Intermittent abdominal pain, nausea, vomiting and diarrhea for 14 mo. 50 pounds of weight loss | Right hemicolectomy followed by 5 cycles of EPOCH (with PEG-asparaginase added in the last cycle) | Developed abdominal pain 15 mo after initial therapy, subsequently passing away around 20 mo after initial diagnosis |
Sato et al[54] | F/52 | Diarrhea and anorexia for 8 wk + 6 kg weight loss | CHOP followed by stem-cell transplant | Unknown |
Kakugawa et al[55] | M/65 | Watery diarrhea for 14 mo | 8 cycles of CHOP followed by 5 cycles of ESHAP | Still alive 67 mo post chemotherapy |
Felipe-Silva et al[56] | M/78 | Diarrhea for 2 mo + 20 kg weight loss | Surgical resection followed by 2 cycles of CHOP, which was changed to COP | 6 mo |
Okumura et al[57] | F/66 | Abdominal distension for 1 mo presenting with acute abdomen | Surgical resection followed by high dose chemotherapy and SCT | Still alive at the time of publication, in complete remission |
Yang et al[58] | M/39 | Acute onset of lower abdominal pain and diffuse peritonitis | Surgical resection | Unknown |
Fukushima et al[59] | M/60 | Severe diarrhea | CHOP | 1 year |
Liong et al[60] | M/50 | Diarrhea for 6 mo, presenting with acute abdomen due to intestinal perforation | Surgical resection followed by CHOP | 4 mo |
Noh et al[61] | M/68 | Nausea and vomiting for 6 mo + 25 kg weight loss | Surgical resection followed by chemotherapy (unspecified) | Unknown |
Hashimoto et al[62] | M/64 | Diarrhea for several months | Chemotherapy (unspecified) | Unknown |
Liu et al[63] | F/43 | Upper abdominal pain and weight loss for 3 mo | 4 cycles of CHOEP and 2 cycles of DHAP followed by surgery | 11 mo after diagnosis, 1 d after surgery due to septic shock |
Fukushima et al[64] | F/68 | Upper abdominal pain and nausea | Laparoscopic intestinal resection followed by auto-peripheral blood SCT | 22 mo without recurrence; passed away 1 mo after duodenal recurrence in 23rd mo |