Sporadic fundic gland polyps with dysplasia or carcinoma: Clinical and endoscopic characteristics

Table 1 Summary of reported cases of sporadic fundic gland polyps with dysplasia or carcinoma

Ref.	Age in yr	Gender, M/F	Location	Size in mm	Macroscopictype	Endoscopic finding (white light)	Pathology	PPIuse	H. pyloriinfection
Jalving et al[26], 2003	68	M	Body fundus	ND	ND	ND	Dysplasia (high grade)	Yes	Negative
Kawase et al[27], 2009	36	F	Body	10	Sessile	Irregular depression on the top	Carcinoma (intramucosal)	ND	Positive
Tazaki et al [28], 2011	28	F	Upper body (posterior wall)	5	Sessile	Isochromatic/Smooth surface	Dysplasia (adenoma)	No	Negative
	60	F	Upper body (greater curvature)	5	Sessile	Isochromatic/Smooth surface	Dysplasia (adenoma)	No	Negative
	39	F	Upper body (greater curvature)	8	Semi-pedunculated	Partially discolored/Smooth surface	Dysplasia (adenoma)	No	Negative
Jeong et al [29], 2014	49	F	Middle body (anterior wall)	8	Pedunculated	Reddish/Erosive surface	Carcinoma (intramucosal)	No	Negative
Levy et al [30], 2015	56 (median)	M: 29; F: 33	ND	5 (mean)	ND	ND	Dysplasia (low grade)	Yes: 49; No: 3; ND: 10	Negative
Togo et al [31], 2016	68	M	Upper body (anterior wall)	5	Sessile	Reddish	Carcinoma (intramucosal)	No	Negative
	63	F	Upper body (anterior wall)	3	Sessile	Reddish	Carcinoma (intramucosal)	No	Negative
Lloyd et al[32], 2017	53 (mean)	M: 5; F: 20	Body: 14; Fundus: 11; Cardia: 1; ND: 4	< 5: 13; 5-10: 10; > 10: 1; ND: 1	Sessile: 20; Pedunculated: 2; ND: 3	ND	Dysplasia (low grade)	Yes: 17; No: 1; ND: 7	ND
Fukudaet al[33], 2018	55	F	Middle body (greater curvature)	10	Sessile	Distorted surface structure	Dysplasia (low grade); Carcinoma (intramucosal)	Yes	Negative
Straub et al[34], 2018	61 (median)	M: 11; F: 28	ND	ND	ND	ND	Dysplasia (low grade/high grade)	Yes: 32; No/ND: 7	Positive: 1; Negative/ND: 38
Shibukawa et al[35], 2019	51	F	Middle body (greater curvature)	10	Pedunculated	ND	Dysplasia (low grade); Carcinoma (biopsy specimen)	Yes	Negative
				10	Semi-pedunculated	ND	Dysplasia (low grade)
				10	Semi-pedunculated	ND	Dysplasia (low grade)
Nawataet al[36], 2020	70	F	Body (greater curvature)	15	Sessile	Reddish	Carcinoma (intramucosal)	Yes	Negative

F: Female; H. pylori: Helicobacter pylori; M: Male; ND: No data; PPI: Proton pump inhibitor.

Table 2 Summary of the clinical and endoscopic characteristics of sporadic fundic gland polyps with or without dysplasia/carcinoma

	Fundic gland polyps (without dysplasia)	Fundic gland polyps with dysplasia	Fundic gland polyps with carcinoma
Age in yr [range]	50-60 s	56.71[24-88]
		56.71[24-88]	56.01[36-70]
Gender	M < F	M < F
Size in mm [range]	≤ 5	5.41[1-20]
		5.21[1-20]	8.71[3-15]
Endoscopic findings (white light)	Isochromatic/smooth surface	Redness, irregular surface structure, depression, or erosion2
Endoscopic findings (magnifying NBI)	Regularly arranged, white, dot-shaped crypt openings	ND	Irregular microvessels

¹Mean values of the cases presented in Table 1.

²Some fundic gland polyps with dysplasia are isochromatic lesions with smooth surfaces. F: Female; M: Male; NBI: Narrow-band imaging; ND: No data.