Gastrointestinal function testing model using a new laryngopharyngeal pH probe (Restech) in patients after Ivor-Lewis esophagectomy

Table 1 Group assignment of patients with simultaneous laryngopharyngeal and esophageal pH-metry (n = 33)

Restech pH-metry	Esophageal pH-metry
	Normal	Abnormal
Normal	D (n = 4)	A (n = 9)
Abnormal	B (n = 0)	C (n = 20)

Table 2 Follow up time, endoscopic findings and symptoms of patients’ cohort

	n	%
Total	43
Follow up time (d)	Mean 790 (median 574)	Range 106-3640
Mucosal disease
Reflux esophagitis
None	18	42
LA grade A	9	21
LA Grade B	7	16
LA Grade C	5	12
LA Grade D	4	9
Barrett’s	1	2
Symptoms
Heartburn	32	74
Regurgitation	36	84
Dysphagia	20	47
Chest pain	25	58
Atypical symptoms	10	23
Weight loss	20	47

Table 3 Results overview

	Group A		Group C		Group D
	n	%	n	%	n	%
Total	9	100	20	100	4	100
Females	1	11	3	15	2	50
Heartburn	9	100	15	75	0	0
Regurgitation	8	89	17	85	1	25
Dysphagia	4	44	11	55	2	50
Chest Pain	8	89	11	55	0	0
Weight loss	5	56	10	50	2	50
Extraesophageal reflux symptoms	2	22	4	20	1	25
	Mean	Range	Mean	Range	Mean	Range
Age (yr)	59	48-66	61	46-77	69	58-77
BMI (kg/m2)	24.9	19.2-29.1	25	20.5-29.6	23.1	17.6-26.3
Restech
RYAN upright	2.36	2.12-4.26	84.8	10.6-381	2.12	-
RYAN supine	2.17	-	14.4	2.17 – 149.1	2.17	-
Eso-pH
DeMeester score	202.9	27-308.5	242	26.4-319.5	0	-
% time pH < 4	36.4	6.2-71	29.1	3.7-90.7	0.55	0-1.9
Gastric pH	3.2	1.6-6.7	2.62	1.2-5.6	3.9	2-6.7

BMI: Body mass index.

Table 4 Endoscopic findings of subgroups

	Group A		Group C		Group D
	n	%	n	%	n	%
Total	9	100	20	100	4	100
Anastomosis (cm) mean/range	25	20-29	25	20-33	22	21-23
Esophagitis
LA Grade A	4	44	1	5	1	25
LA Grade B	1	11	4	20	0	0
LA Grade C	1	11	3	15	0	0
LA Grade D	1	11	2	10	0	0
Barrett’s	0	0	1	5	0	0

Table 5 Demographic information, endoscopic findings and pH data

	Group 1 (3-6 mo follow up)		Group 2 (6-24 mo follow up)		Group 3 (> 24 mo follow up)
	n	%	n	%	n	%
Total	3	100	19	100	13	100
Females	2	67	5	26	0	0
Esophagitis
LA Grade A	0	0	5	26	1	8
LA Grade B	0	0	2	11	3	23
LA Grade C	0	0	1	5	3	23
LA Grade D	0	0	4	21	0	0
	Mean	Range	Mean	Range	Mean	Range
Follow up time (d)	127	106-167	414	209-652	1322	725-1966
Gastric pH	2.4	2 – 2.8	3.4	1.6-6.7	2.4	1.2-4.8
DeMeester score	159.5	0-273.5	197	0-313.4	281.3	116.5-319.5