Poly adenosine diphosphate-ribosylation, a promising target for colorectal cancer treatment

Table 1 The ongoing clinical trials of poly adenosine diphosphate-ribose polymerase-1 inhibitor for the treatment of colorectal cancer

Drug	Trial ID	Target Indication	Outcome measurement	Arm
Olaparib	NCT04456699	Unresectable or metastatic CRC patients who have not progressed following first-line therapy of FOLFOX with bevacizumab	Primary: PFS (up to 6 yr); Secondary: OS, ORR, DOR, AE (up to 6 yr)	(1) Olaparib; (2) Olaparib + Bevacizumab; (3) 5-FU + Bevacizumab; Triple-arms
Olaparib	NCT04166435	O6-MGMT hypermethylated CRC patients	Primary: ORR (up to 2 yr); Secondary: AE, PFS, OS (up to 2 yr)	Temozolomide + Olaparib; Single-arm
Niraparib	NCT03983993	Patients with metastatic CRC	Primary: Clinical benefit rate (CR + PR + SD, up to 5 yr); Secondary: ORR, DOR, PFS, OS (up to 5 yr)	Niraparib + Panitumumab; Single-arm
Rucaparib	NCT03337087	Treating patients with metastatic CRC up to third-line of prior therapy	Primary: MTD, DLT, ORR (SD, CR, PR; up to 3 yr); Secondary: DCR, PFS, OS, AE (up to 3 yr)	liposomal irinotecan + 5-FU + rucaparib; Single-arm

FOLFOX: Leucovorin + 5-FU + Oxaliplatin; PFS: Progression-free survival; OS: Overall survival; ORR: Objective response rate; DOR: Duration of response; AE: Adverse events; CR: Complete response; PR: Partial response; SD: Stable disease; DLT: Dose-limiting toxicity; MTD: Maximum tolerated dose; DCR: Disease control rate; MGMT: Methylguanine deoxyribonucleic acid methyltransferase.