Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer

Table 1 Staging of pancreatic cancer (from the American Joint Committee on Cancer Staging Manual, 8^th edition[45])

Stage	Tumor
IA	Limited to pancreas, greatest dimension: ≤ 2 cm
IB	Limited to pancreas, greatest dimension: ≥ 2 cm
IIA	The greatest dimension is > 4 cm but there is no metastasis or lymph node involvement
IIB	The greatest dimension is ≤ 2 cm to > 4 cm but the cancer has spread to 1-3 regional lymph nodes
III	The greatest dimension is > 4 cm and there are 4 or more lymph nodes involved or the tumor has invaded the celiac axis, superior mesenteric artery, and/or common hepatic artery, regardless of tumor size or lymph nodes involved. The tumor is unresectable
IV	Metastasis to distant sites, regardless of size or number of lymph nodes involved. Metastasis of pancreatic cancer occurs mainly in the liver, peritoneum, and lungs